ArticleNature communications2026
A single-cell atlas of porcine hematopoietic development.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
Domestic pigs are both a globally important agricultural species and an increasingly valuable biomedical model that bridges the gap between rodents and non-human primates. Thus, a thorough understanding of the developing porcine immune system is important to improve pig health and advance preclinical research. Here, we coupled single-cell transcriptomic analyses with T and B cell receptor profiling to create a comprehensive cell atlas of pig hematopoietic development across fetal liver, bone marrow, and thymus tissues from fetal to adult life. We highlight tissue-specific and age-related features; identify gene modules underlying B cell and T cell development; describe the maturation and diversification of B and T cell receptor repertoires in bone marrow B cells and thymic αβ and γδ T cells; and distinguish transcriptionally distinct subsets of γδ T cells according to their γ chain usage. Our data provide key insights into pig immune system development and contribute a valuable resource for advancing pigs as a model of human blood and immune diseases.
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