Evidence map›Paper›PMID 42420247›Full record

ArticleCell death & disease2026

Calcium influx through T-type calcium channels regulates secondary necrosis and inflammation through recruitment of ATG9A-mediated membrane repair.

Omar F Audi, Dilara C Ozkocak, Chad Johnson, Bo Shi, Jascinta P Santavanond, Caitlin L Vella, Joanne M Hildebrand, Robyn Sharples, Quan Thinh Le, Lesley Cheng Sim and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Omar F Audi *Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Bundoora, VIC, 3086, Australia.
Dilara C Ozkocak *Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Bundoora, VIC, 3086, Australia.
Chad JohnsonDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Bundoora, VIC, 3086, Australia.
Bo ShiDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Bundoora, VIC, 3086, Australia.
Jascinta P SantavanondDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Bundoora, VIC, 3086, Australia.ORCID http://orcid.org/0000-0002-7950-6316
Caitlin L VellaDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Bundoora, VIC, 3086, Australia.ORCID http://orcid.org/0009-0009-6556-7861
Joanne M HildebrandThe Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia.
Robyn SharplesDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Bundoora, VIC, 3086, Australia.
Quan Thinh LeDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Bundoora, VIC, 3086, Australia.ORCID http://orcid.org/0000-0002-5588-9957
Lesley Cheng SimDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Bundoora, VIC, 3086, Australia.
Amy A BaxterDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Bundoora, VIC, 3086, Australia.ORCID http://orcid.org/0000-0001-9843-1914
Mark D HulettDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Bundoora, VIC, 3086, Australia.ORCID http://orcid.org/0000-0003-2072-5968
Ivan K H PoonDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Bundoora, VIC, 3086, Australia. i.poon@latrobe.edu.au.ORCID http://orcid.org/0000-0002-9119-7173
Thanh Kha PhanDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Bundoora, VIC, 3086, Australia. kha.phan@latrobe.edu.au.ORCID http://orcid.org/0000-0001-5802-1603

Funding

Department of Health | National Health and Medical Research Council (NHMRC) GNT1173662Department of Health | National Health and Medical Research Council (NHMRC) NHMRC 2025759
6 · The paper itself

Abstract

Approximately 200-300 billion cells die daily through apoptosis, a prominent form of programmed cell death, to maintain tissue homoeostasis. If apoptotic cells are not efficiently removed by phagocytes, they progress to secondary necrosis when the plasma membrane (PM) becomes permeabilised and release proinflammatory damage-associated molecular patterns (DAMPs) such as HMGB1 and ATP, which drive inflammation and contribute to autoimmune diseases. Thus, controlling inflammation through maintaining PM integrity is critical, however the molecular mechanisms underpinning this is not well defined. Here, we reveal a calcium-dependent process that delays secondary necrosis by promoting PM repair. Mechanistically, calcium influx through T-type voltage-gated calcium channels mediates the recruitment of the lipid scramblase ATG9A and Golgi components to damaged PM regions, thereby preventing early cellular lysis and DAMP release. Inhibition of calcium influx or loss of ATG9A accelerates PM rupture, increases DAMP secretion, and exacerbates inflammatory cell recruitment in vivo. Taken together, this study establishes a novel role for T-type calcium channels and ATG9A in regulating PM repair during apoptosis and highlights their therapeutic potential for controlling unwanted inflammation.

Indexed as

Autophagy-Related ProteinsCalciumCalcium Channels, T-TypeCell MembraneInflammationMembrane ProteinsNecrosisPhospholipid Transfer ProteinsVesicular Transport ProteinsAnimalsApoptosisGolgi ApparatusHumansMiceAutophagy-Related ProteinsCalciumCalcium Channels, T-TypeMembrane ProteinsPhospholipid Transfer ProteinsVesicular Transport Proteins

Identifiers

PMID42420247
PMCPMC13631255

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.