ArticleThe Journal of veterinary medical science2026
Copper analysis of laparoscopic liver biopsy tissue samples from cats.
Article in The Journal of veterinary medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatic copper accumulation is assessed qualitatively via histopathology, and hepatic copper concentration is measured quantitatively. Laparoscopic biopsy provides samples adequate for histopathology; however, its suitability for copper quantification in cats remains unclear. Liver tissue samples from 19 cats undergoing laparoscopic liver biopsy were evaluated for hepatic copper score and concentration. Copper scores were determined by a board-certified pathologist using rhodanine-stained sections. Hepatic copper concentrations were determined using atomic absorption spectrometry, and the rhodanine-positive pixel ratio was calculated from histological images using ImageJ. Copper-associated hepatopathy was identified in three cats: two with a score of 4 and one with a score of 5. Seven cats demonstrated cholangiohepatitis (scores 0-3). The hepatic copper score was significantly correlated with copper concentration in the 19 cats (Spearman's r=0.757, P<0.001). Rhodanine-positive pixel ratio also correlated with copper concentration (Spearman's r=0.668, P<0.01). Therefore, laparoscopic biopsy provides feline liver tissue feasible for qualitative and quantitative copper analysis. The liver rhodanine-positive pixel ratio offers a useful quantitative alternative when hepatic copper concentration cannot be measured in cats.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.