Evidence map›Paper›PMID 42419445›Full record

ArticleDevelopmental biology2026

Intracellular pH dynamics promotes zebrafish larval tail regeneration.

Cambria Chou-Freed, Christopher K Prinz, Anush Margaryan, Julie A Theriot, Daniel E Wagner, Diane L Barber

Abstract read
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In one paragraph

Article in Developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Cambria Chou-FreedDepartment of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA, 94143, USA.
Christopher K PrinzDepartment of Biology, University of Washington, Seattle, WA, 98195, USA; Howard Hughes Medical Institute, University of Washington, Seattle, WA, 98195, USA.
Anush MargaryanDevelopmental & Stem Cell Biology Program, University of California San Francisco, San Francisco, CA, 94143, USA.
Julie A TheriotDepartment of Biology, University of Washington, Seattle, WA, 98195, USA; Howard Hughes Medical Institute, University of Washington, Seattle, WA, 98195, USA.
Daniel E WagnerDepartment of Obstetrics, Gynecology and Reproductive Science, Center for Reproductive Sciences, University of California San Francisco, San Francisco, CA, 94143, USA; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, 94143, USA. Electronic address: daniel.wagner@ucsf.edu.
Diane L BarberDepartment of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA, 94143, USA. Electronic address: diane.barber@ucsf.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intracellular pH (pHi) dynamics regulates numerous cellular processes, including migration and proliferation. While these functions are well-established in cell lines, the role of pHi changes in vivo is less well understood. We generated a transgenic zebrafish line expressing a fluorescent ratiometric pHi biosensor and identified functional changes in pHi during zebrafish larval tail regeneration. We found that tail amputation led to a transient decrease in pHi, followed by a prolonged increase in pHi above pre-amputation values. Moreover, we showed that pharmacologically inhibiting Na

Indexed as

RegenerationTailZebrafishAnimalsAnimals, Genetically ModifiedCell ProliferationGlycogen Synthase Kinase 3Hydrogen-Ion ConcentrationLarvaReactive Oxygen SpeciesSodium-Hydrogen ExchangersGlycogen Synthase Kinase 3Reactive Oxygen SpeciesSodium-Hydrogen Exchangers

Identifiers

PMID42419445

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.