ArticleAdvanced materials (Deerfield Beach, Fla.)2026
Sonoenzymatically Triggered Cascading Degradation of Bioresorbable Materials for On-Demand Transient Triboelectric Implants.
Article in Advanced materials (Deerfield Beach, Fla.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Bioresorbable materials provide temporary biomedical support but often generate wear debris during degradation, leading to immune responses and long-term complications. Here, we present a sonoenzymatic activation (SEA) materials strategy for on-demand, cascading in vivo degradation of bioresorbable systems. By coupling ultrasound-triggered mechanical disintegration with enzyme-catalyzed molecular degradation, we design a bioresorbable composite embedding enzyme-encapsulated, biocompatible metal-organic frameworks (BCEM). Ultrasound-induced cavitation enables temporally controlled enzyme release, which cleaves ester bonds in the polycaprolactone matrix. In vivo, BCEM undergoes rapid mechanical fragmentation within 15 min under medically relevant ultrasound (20 kHz, 1.0 W cm
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