ArticleScience advances2026
Moonlighting role of meiotic SYCP1 in breast cancer: A chromatin-bound regulator of DNA repair, transcription, and drug resistance.
Louise C Brennan, Oleg V Grinchuk, Miguel Pachon-Penalba, Ieng F Sou, Conor J Fawcett, Claudia G Nogueira, Megan Guthrie, Andrew D Bates, Megan Hine, Amanda Thomaz and 4 more
Abstract read
In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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5 · Who and what moneyAuthors and funding
14 authors.
Louise C BrennanInstitute of Systems, Molecular and Integrative Biology, University of Liverpool, Crown Street, Liverpool, UK.ORCID 0000-0003-0324-2665 Oleg V GrinchukChromatin Dynamics and Disease Epigenetics Lab, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Republic of Singapore.ORCID 0000-0002-0746-2705 Miguel Pachon-PenalbaCentre for Cell Biology, Institute of Cell Biology, University of Edinburgh, Michael Swann Building, Max Born Crescent, Edinburgh, UK.
Ieng F SouInstitute of Systems, Molecular and Integrative Biology, University of Liverpool, Crown Street, Liverpool, UK.
Conor J FawcettInstitute of Systems, Molecular and Integrative Biology, University of Liverpool, Crown Street, Liverpool, UK.ORCID 0009-0008-0057-983X Megan GuthrieInstitute of Systems, Molecular and Integrative Biology, University of Liverpool, Crown Street, Liverpool, UK.ORCID 0009-0007-1456-4818 Andrew D BatesInstitute of Systems, Molecular and Integrative Biology, University of Liverpool, Crown Street, Liverpool, UK.ORCID 0009-0008-8633-4322 Megan HineDivision of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, UK.ORCID 0009-0002-4710-4862 Amanda ThomazDivision of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, UK.ORCID 0000-0002-8671-5124 Andew B FieldingDivision of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, UK.ORCID 0000-0002-3170-9966 Owen R DaviesCentre for Cell Biology, Institute of Cell Biology, University of Edinburgh, Michael Swann Building, Max Born Crescent, Edinburgh, UK.ORCID 0000-0002-3806-5403 Wee-Wei TeeChromatin Dynamics and Disease Epigenetics Lab, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Republic of Singapore.ORCID 0000-0003-4952-6567 Urszula L McClurgInstitute of Systems, Molecular and Integrative Biology, University of Liverpool, Crown Street, Liverpool, UK.ORCID 0000-0003-2631-4174 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Maintenance of genome integrity is essential for cellular homeostasis, and its perturbation leads to tumorigenesis. Here, we uncover an unanticipated somatic role for the synaptonemal complex protein SYCP1, previously regarded as strictly meiosis specific, in a broad spectrum of human cancers including breast cancer. Through integrative genomic, proteomic, and functional analyses, we demonstrate that SYCP1 is aberrantly reexpressed in tumor cells, where it actively promotes DNA damage repair, cell cycle progression, and malignant growth. SYCP1 binds chromatin at regulatory elements and directly controls transcriptional programs governing genome maintenance, including key effectors such as
Indexed as
Breast NeoplasmsChromatinDNA RepairDrug Resistance, NeoplasmMeiosisTranscription, GeneticCell Line, TumorCell ProliferationCisplatinFemaleGene Expression Regulation, NeoplasticHumansChromatinCisplatin
Identifiers
PMID42418586
PMCPMC13344282
What OpenQuestion holds
Textmetadata
LicenceCC BY
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