Evidence map›Paper›PMID 42418582›Full record

ArticleScience advances2026

Parallel anterior cingulate cortex pathways underlie dissociable social and attentional outputs.

Feidi Wang, Mingyue Chen, Mi Lyu, Ying Zhang, Huan Sun, Yu Lu, Dongqi Cui, Wenting Xu, Yixuan Lyu, Yifang Zhai and 7 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Feidi WangDepartment of Psychiatry, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.ORCID 0009-0004-0742-2836
Mingyue ChenCenter for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.ORCID 0009-0006-3904-482X
Mi LyuCenter for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.ORCID 0009-0002-0702-6054
Ying ZhangCenter for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.ORCID 0000-0002-7931-0348
Huan SunCenter for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Yu LuCenter for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Dongqi CuiCenter for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.ORCID 0009-0006-3755-6338
Wenting XuDepartment of Psychiatry, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Yixuan LyuCenter for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.ORCID 0009-0008-8455-3038
Yifang ZhaiCenter for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Jiao HanCenter for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Jun LiPeking University Sixth Hospital, NHC Key Laboratory of Mental Health, National Clinical Research Center for Mental Disorders, Peking University Institute of Mental Health, Beijing 100083, China.ORCID 0000-0001-6448-8568
Han XuSchool of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.ORCID 0000-0001-6967-9101
Wenting WangDepartment of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an 710032, China.ORCID 0000-0002-8344-0102
Li ChenGrowth, Development and Mental Health Center of Children and Adolescents, Children's Hospital of Chongqing Medical University, Chongqing 401146, China.ORCID 0000-0002-1766-5418
Xiancang MaDepartment of Psychiatry, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.ORCID 0000-0002-7826-305X
Yan LiDepartment of Psychiatry, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.ORCID 0000-0002-7465-7705

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The neural mechanisms coordinating social behavior and attentional control are often disrupted together in individuals with neuropsychiatric disorders such as autism spectrum disorder (ASD); however, how distinct circuits within a shared brain region separately regulate these functions remains unclear. Here, we identified two functionally distinct subpopulations of glutamatergic neurons in the anterior cingulate cortex (ACC) that project to different downstream targets: the zona incerta (ZI) and the limbic sector of the thalamic reticular nucleus (lTRN). These two ACC subpopulations differentially mediate social interaction and attentional allocation. Deficits in both behaviors were observed in

Indexed as

AttentionAutism Spectrum DisorderGyrus CinguliNeural PathwaysSocial BehaviorAnimalsBehavior, AnimalDisease Models, AnimalMaleMiceMicrofilament ProteinsNerve Tissue ProteinsNeuronsOptogeneticsZona IncertaMicrofilament ProteinsNerve Tissue ProteinsShank3 protein, mouse

Identifiers

PMID42418582
PMCPMC13344370

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.