Evidence map›Paper›PMID 42418498›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Mapping the dialogue: Decoding alveolar stem-niche interactions.

Ahmad N Nabhan, Anne Biton, Christine Everett, Conrad Foo, Diana Wu, Joshua D Webster, Alina A Alam, Elisa Penna, Sandra Rost, Neha Rohatgi and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Mapping the dialogue: Decoding alveolar stem-niche interactions.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ahmad N NabhanDepartment of Molecular and Cellular Biology, University of California, Berkeley, CA 94720.
Anne BitonComputational Sciences, Genentech, South San Francisco, CA 94080.
Christine EverettDepartment of Molecular Discovery and Cancer Cell Biology, Genentech, South San Francisco, CA 94080.
Conrad FooDepartment of Pathology, Genentech, South San Francisco, CA 94080.
Diana WuDepartment of Molecular Discovery and Cancer Cell Biology, Genentech, South San Francisco, CA 94080.
Joshua D WebsterDepartment of Pathology, Genentech, South San Francisco, CA 94080.
Alina A AlamDepartment of Molecular and Cellular Biology, University of California, Berkeley, CA 94720.
Elisa PennaDepartment of Pathology, Genentech, South San Francisco, CA 94080.
Sandra RostDepartment of Pathology, Genentech, South San Francisco, CA 94080.
Neha RohatgiRoche Informatics, Hoffman-La Roche Canada, Mississauga, ON, Canada.
Rohit RejaComputational Sciences, Genentech, South San Francisco, CA 94080.
Ranel J TulpanoDepartment of Molecular and Cellular Biology, University of California, Berkeley, CA 94720.
Shiqi XieDepartment of Molecular Discovery and Cancer Cell Biology, Genentech, South San Francisco, CA 94080.
Celine EidenschenkDepartment of Molecular Discovery and Cancer Cell Biology, Genentech, South San Francisco, CA 94080.
Kim NewtonDepartment of Physiological Chemistry, Genentech, South San Francisco, CA 94080.
Joseph R ArronDepartment of Immunology, Genentech, South San Francisco, CA 94080.
Vishva M DixitDepartment of Physiological Chemistry, Genentech, South San Francisco, CA 94080.ORCID 0000-0001-6983-0326

Funding

Roche Holding | Genentech (Genentech USA) NA
6 · The paper itself

Abstract

While cellular atlases have revealed remarkable phenotypic diversity, how cells navigate this landscape to influence tissue behavior remains poorly understood. We present an alveolosphere screening platform for investigating interactions between lung stem cells and their fibroblast niche. We assessed the role of 201 candidate genes in stem cells via imaging, then used chimeric RNAseq analysis for a transcriptome-wide understanding of cell-autonomous effects on stem cells and non-cell-autonomous effects on the niche. This phenome-transcriptome map uncovered cellular states and pathways regulating proliferation, metabolism, and immune signaling. Notably, stem cells influenced scar-forming and immune programs in fibroblasts. This injury response was dependent on stem cell identity; loss of

Indexed as

Pulmonary AlveoliStem Cell NicheStem CellsAnimalsFibroblastsLungMiceSignal TransductionThyroid Nuclear Factor 1TranscriptomeNkx2-1 protein, mouseThyroid Nuclear Factor 1epitheliumfibroblastlungnicheNkx2.1

Identifiers

PMID42418498
PMCPMC13367804

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.