Evidence map›Paper›PMID 42418250›Full record

ArticleDrug development research2026

Structure-Based Design, Synthesis, and Biological Evaluation of Oxadiazole-Morpholine Hybrids as Potent PARP-1 Inhibitors Inducing Apoptosis in Breast Cancer Cells.

Nader R Albujuq, Khaled M Darwish, Sherif Ashraf Fahmy, Buthaina Hussein, Ghada G Kayed, Musa A Said, Mohamed S Nafie

Abstract read
In one paragraph

Article in Drug development research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nader R AlbujuqDepartment of Chemistry, School of Science, The University of Jordan, Amman, Jordan.
Khaled M DarwishMedicinal Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.ORCID https://orcid.org/0000-0002-0597-482X
Sherif Ashraf FahmyDepartment of Pharmacy, Institute of Pharmaceutics and Biopharmaceutics, Marburg University, Marburg, Germany.ORCID https://orcid.org/0000-0003-3056-8281
Buthaina HusseinDepartment of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Jordan.ORCID https://orcid.org/0000-0002-9344-0587
Ghada G KayedFaculty of science, Zarqa University, Zarqa, Jordan.
Musa A SaidDepartment of Chemistry, Faculty of Science, Islamic University of Madinah, Madinah, Saudi Arabia.
Mohamed S NafieDepartment of Chemistry, College of Sciences, University of Sharjah, Sharjah, United Arab Emirates.ORCID https://orcid.org/0000-0003-4454-6390

Funding

Alexander von Humboldt-StiftungPhilipps-Universität MarburgUniversity of Jordan
6 · The paper itself

Abstract

Poly(ADP-ribose) polymerase-1 (PARP-1) plays a central role in the repair of DNA single-strand breaks and represents an established therapeutic target in cancer treatment. In this study, a series of novel oxadiazole-morpholine hybrid compounds was designed and synthesized using a structure-based drug design approach to target the catalytic domain of PARP-1. The synthesized compounds were evaluated for their cytotoxic activity against breast and ovarian cancer cells, PARP-1 inhibitory potency, and apoptosis-inducing effects. Among the tested compounds, 12a exhibited potent cytotoxic activity against MDA-MB-231 cells (IC

Indexed as

Antineoplastic AgentsBreast NeoplasmsMorpholinesOxadiazolesPoly (ADP-Ribose) Polymerase-1Poly(ADP-ribose) Polymerase InhibitorsApoptosisCell Line, TumorDrug DesignFemaleHumansMDA-MB-231 CellsMolecular Docking SimulationPiperazinesStructure-Activity RelationshipAntineoplastic AgentsmorpholineMorpholinesOxadiazolesPARP1 protein, humanPiperazinesPoly (ADP-Ribose) Polymerase-1Poly(ADP-ribose) Polymerase Inhibitorsapoptosis inductionbreast canceroxadiazolePARP‐1 inhibitionsynthesis

Identifiers

PMID42418250
PMCPMC13344874

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.