ArticlePediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2026
Predicting the course of chronic rhinosinusitis in young children-5-year prospective study.
Article in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03011632 (The Role of Nonspecific Immune Response of the Airway Mucosa in Children With Chronic Rhinosinusitis and Asthma), which is not on this map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of Nonspecific Immune Response of the Airway Mucosa in Children With Chronic Rhinosinusitis and Asthma
Who cites it
1 citing paper in PubMed.
- Predicting the course of chronic rhinosinusitis in young children-5-year prospective study.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundPredicting the course of chronic rhinosinusitis (CRS) and assessing the clinical relevance of IgE-mediated sensitization to house dust mite (HDM) in preschool children remain challenging. We aimed to identify early clinical characteristics of HDM-induced allergic rhinitis (AR-HDM) in preschoolers and to determine predictors of CRS persistence.
methodsWe conducted a 5-year prospective follow-up of a well-defined multi-omics cohort of 133 children aged 4-8 years with CRS symptoms, with or without IgE-mediated sensitization to HDM. We developed a multivariate logistic regression model with clinical and multi-omics variables assessed at preschool age to predict CRS persistence and AR-HDM diagnosis at school age.
resultsAmong 117 children who completed the 5-year follow-up, CRS persisted in 35%. Higher baseline SN-5 (Sinus and Nasal Quality of Life Survey) scores (>3.6 points) significantly increased the risk of persistent CRS (OR = 3.41; 95% CI: 1.50-7.76; p = .003). ILC-2 cells were detected more frequently in nasal samples from preschool children with persistent CRS. Independent predictors of AR-HDM included a history of food allergy in infancy (OR = 3.87; 1.10-13.60; 0.034) and prominent allergic symptoms at baseline (allergy-related SN-5 domain ratio ≥21%), (OR = 3.96; 1.20-13.10; 0.025). The combined presence of these factors additionally improves the prediction of AR-HDM.
conclusionsHigher SN-5 score and presence of ILC-2 in the nasal mucosa increase the risk of persistence of CRS. The co-occurrence of a relatively higher allergy domain of SN-5 score and a history of food allergy facilitates prediction of HDM allergy in preschoolers, enabling the timely initiation of allergen immunotherapy in allergic children.
trial registrationClinicalTrials.gov Identifier: NCT03011632.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.