Evidence map›Paper›PMID 42418173›Full record

ArticleJournal of the American Chemical Society2026

Carbonylative Aminative Suzuki-Miyaura Coupling: Pd-Catalyzed Synthesis of Amides from Vinyl/Aryl Halides and Boronic Acids.

Jianhan Zhou, Dalton Raykowski, Zuzanna Kowalski, Shangyu Li, Yifan Ping, Yongrui Luo, Eugene E Kwan, Richard Y Liu

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jianhan ZhouDepartment of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States.ORCID 0000-0001-5886-7174
Dalton RaykowskiDepartment of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States.
Zuzanna KowalskiDepartment of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States.ORCID 0009-0005-0136-3326
Shangyu LiDepartment of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States.ORCID 0009-0009-9820-1997
Yifan PingDepartment of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States.ORCID 0009-0009-7132-4786
Yongrui LuoDepartment of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States.ORCID 0000-0001-9137-2595
Eugene E KwanProcess Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States.ORCID 0000-0001-7037-0531
Richard Y LiuDepartment of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States.ORCID 0000-0003-0951-6487

Funding

Organic Pseudometals to Sustain and Transform Small-Molecule Drug SynthesisDP2GM164340 · NIGMS · HARVARD UNIVERSITY · PI LIU, RICHARD · 2025 to 2025
$1.5M
NIGMS NIH HHS DP2 GM164340
6 · The paper itself

Abstract

Amide synthesis is critical for the development of pharmaceuticals, agrochemicals, and functional materials. Here, we report a four-component variant of the Pd-catalyzed Suzuki-Miyaura coupling that repurposes partners conventionally used for C-C bond formation to instead yield amides. The sequential insertion of CO, from Mo(CO)

Identifiers

PMID42418173
PMCPMC13348726

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.