Evidence map›Paper›PMID 42418134›Full record

ArticleThe international journal of cardiovascular imaging2026

Multimodality imaging of myocardial injury and coronary microvascular dysfunction in congenital thrombotic thrombocytopenic purpura.

Ayush Kumar, Leonid Khokhlov, Robert O'Donnell

Abstract read
PubMed Publisher
In one paragraph

Article in The international journal of cardiovascular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ayush KumarDepartment of Internal Medicine, University of Cincinnati Medical Center, Cincinnati, OH, USA.
Leonid KhokhlovDivision of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati Medical Center, Cincinnati, OH, USA.
Robert O'DonnellDivision of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati Medical Center, Cincinnati, OH, USA. odonnert@ucmail.uc.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Congenital thrombotic thrombocytopenic purpura is an ultra-rare autosomal recessive disorder associated with mutations in the ADAMTS13 gene. The gene product is an enzyme responsible for cleavage of ultra-large von Willebrand factor multimers, and severe deficiency results in a thrombotic microangiopathy. We present the case of subclinical cardiac involvement characterized by myocardial fibrosis/scarring and impaired myocardial flow reserve in an affected patient who temporarily discontinued enzyme replacement therapy. This case highlights the complementary value of cardiac magnetic resonance and PET myocardial perfusion imaging in congenital thrombotic thrombocytopenic purpura where subclinical myocardial injury may coexist with impaired myocardial flow reserve despite the absence of focal inducible ischemia.

Indexed as

Cardiac magnetic resonanceCoronary flow reserveMicrovascular dysfunctionPositron emission tomographyThrombotic thrombocytopenic purpura

Identifiers

PMID42418134

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.