Evidence map›Paper›PMID 42418061›Full record

ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2026

Streptococcal toxic shock syndrome caused by ST525 Streptococcus dysgalactiae subsp. equisimilis with genomic characterization of virulence and antimicrobial resistance.

Shuma Tsuji, Shinnosuke Fukushima, Kazuyoshi Gotoh, Koji Iio, Maki Tanioka, Hideharu Hagiya

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Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Shuma TsujiDepartment of Medical Laboratory Science, Okayama University Graduate School of Health Sciences, Okayama, Japan.
Shinnosuke FukushimaDepartment of Infectious Diseases, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Kazuyoshi GotohDepartment of Medical Laboratory Science, Okayama University Graduate School of Health Sciences, Okayama, Japan.
Koji IioMicrobiology Division, Clinical Laboratory, Okayama University Hospital, Okayama, Japan.
Maki TaniokaClinical Oncology Center, Okayama University Hospital, Okayama , Japan.
Hideharu HagiyaResearch Center for Intestinal Health Science, Okayama University, Okayama, Japan. hagiya@okayama-u.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Streptococcus dysgalactiae subsp. equisimilis (SDSE) is an emerging cause of severe invasive infections. We describe the clinical course of an immunocompromised patient with advanced breast cancer who developed streptococcal toxic shock syndrome, necrotizing fasciitis, and disseminated intramuscular abscesses caused by a multidrug-resistant Lancefield group G SDSE isolate, alongside a comprehensive genomic characterization of its virulence and antimicrobial resistance profiles. Genomic analysis identified the isolate as emm subtype stG840.0 and sequence type 525 (ST525), harboring genes encoding several virulence-associated factors, including an emm-like gene encoding an M-like surface protein, streptokinase, streptolysin O, streptolysin S, and SpeG. Through comprehensive genomic analysis of the highly virulent SDSE isolate, we provided insights into its underlying genetic background. Further accumulation of genomic data is expected to fully elucidate the mechanisms of virulence and antimicrobial resistance in SDSE.

Indexed as

emm typingMultilocus sequence typingNecrotizing fasciitisStreptococcal toxic shock syndromeStreptococcus dysgalactiae subsp. equisimilisWhole-genome sequencing

Identifiers

PMID42418061

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