Evidence map›Paper›PMID 42418060›Full record

ArticleMedical oncology (Northwood, London, England)2026

IFITM3 promotes an M2-like tumor-supportive microenvironment in acute myeloid leukemia.

Fang Zhou, Yi Zhang, JiaHeng Guan, Lin Gui, Baoan Chen

Abstract read
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In one paragraph

Article in Medical oncology (Northwood, London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fang ZhouDepartment of Hematology, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, China.
Yi ZhangDepartment of Hematology, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, China.
JiaHeng GuanDepartment of Hematology, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, China.
Lin GuiDepartment of Hematology, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, China. guilinnj@seu.edu.cn.
Baoan ChenDepartment of Hematology, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, China. bachen@seu.edu.cn.

Funding

the Social Science and Technology Development Project of Jiangning District Science and Technology Bureau, Nanjing City 2019SHSY0034
6 · The paper itself

Abstract

Interferon-induced transmembrane protein 3 (IFITM3) is overexpressed in acute myeloid leukemia (AML) and is associated with poor prognosis. Previous studies implicate IFITM3 in oncogenic processes and immune modulation; however, the mechanisms by which IFITM3 contributes to leukemogenesis and shapes the AML immune microenvironment remain unclear. Here, we integrated single-cell RNA sequencing (scRNA-seq) and bulk gene expression analyses with macrophage polarization assays using IFITM3

Indexed as

Leukemia, Myeloid, AcuteMacrophagesMembrane ProteinsRNA-Binding ProteinsTumor MicroenvironmentCell Line, TumorHL-60 CellsHumansIFITM3 protein, humanMembrane ProteinsRNA-Binding ProteinsAMLIFITM3MacrophageMicroenvironment

Identifiers

PMID42418060

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.