ArticleMetabolic brain disease2026
Reduced cortical gyrification in type 1 diabetes is associated with white matter integrity loss and cognitive decline.
Article in Metabolic brain disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Type 1 diabetes-related cognitive declines suggest cortical involvement, despite cortical volume and thickness failing to account for these changes. The local gyrification index (LGI), which quantifies the complexity of cortical folding, could therefore provide additional information about cerebral integrity. This study aimed to determine differences in LGI in type 1 diabetes (T1D) in relation to the white matter integrity of connecting fibers and cognitive functioning. Fifty-one T1D participants with microangiopathy, 53 without, and 49 healthy controls underwent MR-imaging and neuropsychological assessment. LGI was calculated using FreeSurfer6. Probabilistic tractography was performed with MRtrix3. Group analyses were adjusted for age, sex, systolic blood pressure; and for multiple comparisons using Family Wise Error (FWE). Mediation analysis was performed with Python. LGI was broadly reduced across T1D participants, primarily driven by those with microangiopathy (all P
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