Evidence map›Paper›PMID 42417991›Full record

ArticleSocial psychiatry and psychiatric epidemiology2026

Association of induced abortion with bipolar disorder and major depression from the UK Biobank: a propensity score matching and weighting analysis.

Hao Sun, Can Liu, Yuying Wang, Huan Liu, Yanjie Chen, Ziyan Chu, Hongpeng Sun, Liping Tan, Zaixiang Tang

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In one paragraph

Article in Social psychiatry and psychiatric epidemiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Hao Sun *The Second Affiliated Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou, 215004, Jiangsu, PR China.
Can Liu *Department of Biostatistics, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non-communicable Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou, 215123, Jiangsu, PR China.
Yuying WangDepartment of Biostatistics, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non-communicable Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou, 215123, Jiangsu, PR China.
Huan LiuDepartment of Biostatistics, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non-communicable Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou, 215123, Jiangsu, PR China.
Yanjie ChenDepartment of Biostatistics, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non-communicable Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou, 215123, Jiangsu, PR China.
Ziyan ChuDepartment of Biostatistics, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non-communicable Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou, 215123, Jiangsu, PR China.
Hongpeng SunDepartment of Biostatistics, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non-communicable Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou, 215123, Jiangsu, PR China.
Liping TanThe Second Affiliated Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou, 215004, Jiangsu, PR China. tlping67@126.com.
Zaixiang TangThe Second Affiliated Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou, 215004, Jiangsu, PR China. tangzx@suda.edu.cn.

Funding

Identifying Genes Related to Radiosensitivity of Endometrial Cancer Based on Immunity and Tumor Microenvironment and Constructing a Prediction Model for Radiosensitivity SGK1202407Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases KJS2222National Natural Science Foundation of China 82373688Priority Academic Program Development of Jiangsu Higher Education Institutions at Soochow University, the State Key Laboratory of Radiation Medicine and Protection GZK1201919Suzhou Key Laboratory of Neuro-oncology and Nano-bionics SZZD003
6 · The paper itself

Abstract

objectivesThis study aimed to investigate the association between induced abortion (IA) and bipolar disorder and major depression (BDMD), and explore the dose-response relationship between them.

methodsWe used cross-sectional data including 13,200 females from the UK Biobank. Self-reported IA was categorized into two groups: Non-IA(no history of induced abortion) and IA(≥ 1 induced abortions). Covariates adjustment, propensity score matching (PSM), and inverse probability of treatment weighting (IPTW) were used to balance the baseline characteristics of the two groups. A three-knot restricted cubic spline regression model was used to examine the dose-response relationship between the number of IAs and BDMD.

resultsIPTW multivariable logistic regression and PSM multivariable logistic regression analyses indicated that there was a significant association between IA and BDMD, with odds ratios (ORs) of 1.25 (95% confidence interval [CI]: 1.19 to 1.32) and 1.25 (95% CI: 1.10 to 1.41), respectively. There was a significant positive association between the number of IAs and BDMD. Specifically, for individuals reporting 1-2 IAs compared to none, the ORs were 1.25 (95% CI: 1.18 to 1.32) and 1.23 (95% CI: 1.09 to 1.40), and for those with ≥ 3 IAs, the ORs were 1.32 (95% CI: 1.10 to 1.59) and 1.55 (95% CI: 1.13 to 2.34). The three-knot restricted cubic spline regression model revealed a nonlinear relationship between the number of IAs and BDMD.

conclusionThere is a significant association between IA and BDMD. Therefore, mental health care for women who reported experiencing induced abortion is crucial.

Indexed as

Abortion, InducedBipolar DisorderMajor Depressive DisorderAdultBiological Specimen BanksCross-Sectional StudiesFemaleHumansLogistic ModelsMiddle AgedPregnancyPropensity ScoreUK BiobankUnited KingdomBipolar disorderInduced abortionIPTWMajor depressionPSMUK Biobank

Identifiers

PMID42417991

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.