ArticleSports medicine - open2026
Exploration of Exercise-Induced Gastrointestinal Syndrome in Endurance-Trained Adolescents: Is There Cause for Concern in Regard to Ultra-endurance Event Participation.
Article in Sports medicine - open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundExercise-induced gastrointestinal syndrome (EIGS) in response to prolonged exercise is well-established in adult athletes but no study has investigated how EIGS presents in adolescent athletes despite an increase in youth participation in ultramarathon events. This study aimed to determine the impact of prolonged exercise on gastrointestinal integrity, functional responses, systemic immune profile, and gastrointestinal symptoms (GIS) in youth (YOUTH) vs adult (ADULTS) athletes.
methodsTwelve youth (≤ 18y) and twelve adults (≥ 30-50y) completed 3 h treadmill running at 60% V̇O
resultsThere was no difference in pre-to-post-exercise concentrations of plasma cortisol, elastase, I-FABP, sCD14, TNF-α, or IL-10 between YOUTH and ADULTS (p > 0.05). YOUTH had higher total leukocyte and neutrophil counts (p < 0.05) in response to exercise [mean (95% CI) 13.1 (10.6 to 15.5) × 10
conclusionsThe pathways of EIGS in response to exercise do not substantially differ in youth vs adult athletes. Therefore, EIGS and Ex-GIS management strategies for adult athletes are likely transferable to youth athletes. Further studies investigating the use of these specific strategies in youth athletes are required to confirm this.
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