Evidence map›Paper›PMID 42417912›Full record

ArticleBiochemical genetics2026

Expression of Transforming Growth Factor Beta 1 in Lung Adenocarcinoma and Its Relationship with Circulating Tumour Cells.

Ning Chen, Duo-Jun Qiu, Jian-Zhu Yang, Gui-Yun Zhu, Li-Fei Kang, Xiao-Ying An, Zhi-Ming Xu, Xiao-Xia Li

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Article in Biochemical genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Ning ChenDepartment of Pathology, The First Hospital of Hebei Medical University, 89 Donggang Road, Shijiazhuang, 050031, China.
Duo-Jun QiuDepartment of Pathology, The First Hospital of Hebei Medical University, 89 Donggang Road, Shijiazhuang, 050031, China.
Jian-Zhu YangDepartment of Pathology, The First Hospital of Hebei Medical University, 89 Donggang Road, Shijiazhuang, 050031, China.
Gui-Yun ZhuDepartment of Pathology, Hebei Chest Hospital, 372 Shengli North Street, Chang'an District, Shijiazhuang, 050041, China.
Li-Fei KangDepartment of Pathology, Hebei Chest Hospital, 372 Shengli North Street, Chang'an District, Shijiazhuang, 050041, China.
Xiao-Ying AnDepartment of Pathology, Hebei Chest Hospital, 372 Shengli North Street, Chang'an District, Shijiazhuang, 050041, China.
Zhi-Ming XuDepartment of Pathology, Hebei Chest Hospital, 372 Shengli North Street, Chang'an District, Shijiazhuang, 050041, China.
Xiao-Xia LiDepartment of Pathology, Hebei Chest Hospital, 372 Shengli North Street, Chang'an District, Shijiazhuang, 050041, China. xia38o_xiad2m3v@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To investigate the relationship between the expression of transforming growth factor beta 1 (TGF-β1), epithelial-mesenchymal transition (EMT)-related proteins, circulating tumour cells (CTCs) positivity rate and tumour differentiation degree in lung adenocarcinoma. A prospective study was conducted, including 78 patients with lung adenocarcinoma who underwent surgical resection at our hospital between March 2021 and December 2021. Clinical data, lung adenocarcinoma and adjacent tissues were collected. Western blot, immunohistochemistry and RT-PCR were used to detect the expression of TGF-β1, EMT-related proteins (E-cadherin, vimentin) and mRNA in lung adenocarcinoma. Peripheral blood for CTC analysis was collected within 1 week before surgical resection. Pearson correlation analysis was employed to assess the relationship between TGF-β1, EMT and CTCs. There was a significant correlation between the positive rate of CTCs and the degree of tumour differentiation in patients with lung adenocarcinoma (P < 0.05). The expression of TGF-β1 increased significantly as the degree of differentiation decreased (P < 0.05). It was positively correlated with vimentin expression and negatively correlated with E-cadherin expression (P < 0.05). High expression of TGF-β1 in lung adenocarcinoma promotes EMT and the occurrence of CTCs and is associated with the degree of tumour differentiation.

Indexed as

Circulating tumour cellsEpithelial–mesenchymal transitionLung adenocarcinomaTransforming growth factor beta 1

Identifiers

PMID42417912

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