Evidence map›Paper›PMID 42417504›Full record

ArticleeLife2026

TGF-β drives the conversion of conventional NK cells into uterine tissue-resident NK cells to support murine pregnancy.

Josselyn D Barahona, Liping Yang, D Michael Nelson, Wayne M Yokoyama

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Josselyn D BarahonaDivision of Rheumatology, Department of Medicine, Washington University School of Medicine, St Louis, United States.ORCID 0000-0002-7850-5848
Liping YangDivision of Rheumatology, Department of Medicine, Washington University School of Medicine, St Louis, United States.
D Michael NelsonDepartment of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, United States.
Wayne M YokoyamaDivision of Rheumatology, Department of Medicine, Washington University School of Medicine, St Louis, United States.ORCID 0000-0002-0566-7264

Funding

Eunice Kennedy Shriver National Institute of Child Health and Human Development 1F30HD118750
6 · The paper itself

Abstract

Tissue microenvironments shape lymphocyte differentiation to align immune function with local physiological demands. Uterine natural killer (NK) cells are critical for reproductive success, yet the molecular cues in the uterus that instruct their specialized identities remain incompletely understood. Here, we identify a TGF-β-dependent differentiation pathway by which circulating conventional NK cells convert into uterine tissue-resident NK cells during murine pregnancy. Loss of TGF-β receptor II expression in

Indexed as

Cell DifferentiationKiller Cells, NaturalTransforming Growth Factor betaUterusAnimalsAntigens, LyFemaleMiceMice, Inbred C57BLNatural Cytotoxicity Triggering Receptor 1PregnancyReceptor, Transforming Growth Factor-beta Type IIAntigens, LyNatural Cytotoxicity Triggering Receptor 1Ncr1 protein, mouseReceptor, Transforming Growth Factor-beta Type IITgfbr2 protein, mouseTransforming Growth Factor betaimmunologyinflammationmousenatural killer cellspregnancyTGF-β

Identifiers

PMID42417504
PMCPMC13345626

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.