Evidence map›Paper›PMID 42417107›Full record

ArticleeLife2026

Depletion of extracellular asparagine impairs self-reactive T cells and ameliorates autoimmunity in a murine model of multiple sclerosis.

Peter Georgiev, Sheila Johnson, Kiran Kurmi, Song-Hua Hu, SeongJun Han, Dillon Patterson, Thao H Nguyen, Linglin Huang, Dan Liang, Naomi Goldman and 5 more

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Peter Georgiev *Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, United States.ORCID 0000-0002-4613-1255
Sheila Johnson *Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, United States.ORCID 0000-0001-5062-7934
Kiran KurmiDepartment of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, United States.
Song-Hua HuDepartment of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, United States.
SeongJun HanDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, United States.
Dillon PattersonDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, United States.
Thao H NguyenDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, United States.
Linglin HuangGene Lay Institute of Immunology and Inflammation of Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, United States.
Dan LiangDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, United States.
Naomi GoldmanDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, United States.
Thomas ConwayDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, United States.
Hannah CreaseyDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, United States.
Jared RoweDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, United States.
Marcia C HaigisDepartment of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, United States.ORCID 0000-0003-2530-2681
Arlene H SharpeDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, United States.ORCID 0000-0002-9736-2109

Funding

Role of Negative Costimulation in Regulation of AutoimmunityP01AI039671 · NIAID · YALE UNIVERSITY · PI David A. Hafler · 1996 to 2026
$51.7M
Transgenic/KnockoutP01AI056299 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI BLAZAR, BRUCE R · 2003 to 2023
$42.5M
Defining mechanisms to promote antitumor immunity by modulating one-carbon metabolismR01CA276866 · NCI · HARVARD MEDICAL SCHOOL · PI MARCIA HAIGIS, Arlene H. Sharpe · 2023 to 2026
$2.2M
Progenitor cell states contributing to aging and lung cancerU01CA267827 · NCI · HARVARD MEDICAL SCHOOL · PI HAIGIS, MARCIA, KIM, CARLA F. · 2021 to 2025
$2.2M
CIHR Banting Postdoctoral FellowshipLife Sciences Research Foundation Gilead Sciences FellowshipNIH HHS 1F31CA281090-01NIH HHS AI108545NIH HHS P01 AI039671NIH HHS P01 AI056299NIH HHS R01CA276866NIH HHS U01 CA267827NIH HHS U54 CA224088
6 · The paper itself

Abstract

Amino acids play critical roles in the activation and function of lymphocytes. Here we show that the non-essential amino acid, asparagine, is essential for optimal activation and proliferation of CD4

Indexed as

AsparagineAutoimmunityCD4-Positive T-LymphocytesEncephalomyelitis, Autoimmune, ExperimentalMultiple SclerosisAdoptive TransferAnimalsCytokinesDisease Models, AnimalFemaleLymphocyte ActivationMiceMice, Inbred C57BLTh17 CellsAsparagineCytokinesautoimmune response/diseaseimmunologyinflammationlymphocyte subsetsmouse

Identifiers

PMID42417107
PMCPMC13345630

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.