ArticleJournal of genetics2026
Characterization of an MHC class II b gene reveals high heterogeneity and polymorphism among populations of non-native bullfrogs with complex invasion histories.
Article in Journal of genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
We characterized the genetic diversity of exon 2 of one major histocompatibility complex (MHC) Class II b chain gene in five non-native populations of the American bullfrog (Aquarana (Rana) catesbeiana)-a highly invasive amphibian. We discovered higher levels of genetic diversity and more signatures of positive selection in the MHC exon relative to a putatively neutral protein coding gene (Cytochrome b). Populations (even those in close geographic proximity) harboured highly varying levels of diversity at both loci, including alleles that have been previously shown to be associated with disease resistance in this species.
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