Investigation and computational prediction of gating pore currents in Na

Ahmed Eltokhi, Eslam Elhanafy, Jing Li, Tamer M Gamal El-Din

Abstract read

In one paragraph

Article in PNAS nexus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ahmed EltokhiDepartment of Biomedical Sciences, School of Medicine, Mercer University, Columbus, GA 31901, USA.ORCID https://orcid.org/0000-0001-9067-5017

Eslam ElhanafyDepartment of Biomolecular Sciences, School of Pharmacy, University of Mississippi, Oxford, MS 38677, USA.ORCID https://orcid.org/0000-0002-0125-1958

Jing LiDepartment of Biomolecular Sciences, School of Pharmacy, University of Mississippi, Oxford, MS 38677, USA.ORCID https://orcid.org/0000-0003-3277-6818

Tamer M Gamal El-DinDepartment of Pharmacology, University of Washington, Seattle, WA 98195, USA.ORCID https://orcid.org/0000-0002-7406-7393

Funding

Computational Studies of Molecular Medicine for Voltage-Gated Sodium ChannelsR35GM160133 · NIGMS · UNIVERSITY OF MISSISSIPPI · PI Jing Li · 2025 to 2026

$766k

NIGMS NIH HHS R35 GM160133

6 · The paper itself

Abstract

Voltage sensor domains (VSDs) are integral and common regions within voltage-gated ion channels that play a crucial role in cellular signaling and excitability. Each VSD comprises four transmembrane segments (S1-S4) per domain. The transmembrane segment S4 contains positively charged amino acid residues at every third position, which serve as the channel's gating charges. Over the last decade, it has been shown that these gating charges are the target of many pathological mutations. This study investigates three gating-charge mutations in domain I of the Na

Indexed as

autism spectrum disorderbenign familial neonatal-infantile seizuresdevelopmental and epileptic encephalopathygating pore currentsvoltage-gated sodium channels

Identifiers

PMID42416924

DOI10.1093/pnasnexus/pgag230

PMCPMC13340926

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.