ArticleJournal of human immunity2026
Newborn screening reduces survival disparities in SCID after stem cell transplant: A PIDTC report.
Abstract read
In one paragraph
Article in Journal of human immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
70 authors.
Lena E WinestoneDivision of Pediatric Allergy, Immunology, and Blood and Marrow Transplantation, University of California, San Francisco, San Francisco, CA, USA.ORCID https://orcid.org/0000-0001-9982-1594
Brent R LoganDivision of Biostatistics, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID https://orcid.org/0000-0002-4473-4044
Xuerong LiuDivision of Biostatistics, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID https://orcid.org/0000-0003-1659-6809
Olatundun WilliamsClinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID https://orcid.org/0000-0003-2163-3918
Elizabeth A DunnDivision of Pediatric Allergy, Immunology, and Blood and Marrow Transplantation, University of California, San Francisco, San Francisco, CA, USA.ORCID https://orcid.org/0009-0009-8555-0231
Monica S ThakarClinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID https://orcid.org/0000-0001-5801-5457
Sharon A KiddDivision of Pediatric Allergy, Immunology, and Blood and Marrow Transplantation, University of California, San Francisco, San Francisco, CA, USA.ORCID https://orcid.org/0000-0002-7562-8682
Talal MousallemDepartment of Pediatrics, Division of Pediatric Allergy and Immunology, Duke University School of Medicine, Durham, NC, USA.ORCID https://orcid.org/0000-0002-3692-8930
Morna J DorseyDivision of Pediatric Allergy, Immunology, and Blood and Marrow Transplantation, University of California, San Francisco, San Francisco, CA, USA.ORCID https://orcid.org/0000-0002-9432-3542
Richard J O'ReillyTransplant & Cellular Therapy, MSK Kids, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID https://orcid.org/0000-0002-8997-5490
Neena KapoorTransplant and Cell Therapy Program and Laboratory, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-3352-9651
Lisa Forbes SatterDepartment of Pediatrics, Baylor College of Medicine, Houston, TX, USA.ORCID https://orcid.org/0000-0001-9402-1934
Malika KapadiaDepartment of Pediatrics, Harvard University Medical School, Boston, MA, USA.ORCID https://orcid.org/0009-0000-3959-5441
Soma C JyonouchiDivision of Allergy and Immunology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID https://orcid.org/0009-0007-3802-7347
Sharat ChandraDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID https://orcid.org/0000-0002-2933-814X
Christen L EbensDepartment of Pediatrics, Division of Blood and Marrow Transplantation & Cellular Therapy, University of Minnesota, Minneapolis, MN, USA.ORCID https://orcid.org/0000-0003-2430-911X
Deepakbabu ChellapandianCancer and Blood Disorders Institute, Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA.ORCID https://orcid.org/0000-0003-3518-9790
Sonali ChaudhuryNorthwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID https://orcid.org/0000-0001-9816-5126
Karin ChenDepartment of Pediatrics, University of Washington, Seattle, WA, USA.ORCID https://orcid.org/0000-0001-5593-436X
Blachy J Dávila SaldañaDepartment of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.ORCID https://orcid.org/0000-0001-8281-3627
Ahmad RayesPediatric Immunology and Hematopoietic Cell Transplantation/Cellular Therapy Program, Primary Children's Hospital, University of Utah, Salt Lake City, UT, USA.ORCID https://orcid.org/0000-0002-6352-9740
Troy C QuiggDepartment of Pediatrics, Michigan State University College of Human Medicine, Grand Rapids, MI, USA.ORCID https://orcid.org/0000-0002-5268-7938
Shanmuganathan ChandrakasanDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.ORCID https://orcid.org/0000-0001-8007-9932
Jeffrey J BednarskiDepartment of Pediatrics, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.ORCID https://orcid.org/0000-0001-6902-0876
Kenneth B DeSantesStem Cell & Regenerative Medicine Center, University of Madison-Wisconsin, Madison, WI, USA.ORCID https://orcid.org/0000-0002-9092-0139
Pierre TeiraDepartment of Pediatrics, Department of Microbiology, Immunology and Infectious Diseases, Centre de Recherche Azrieli du CHU Sainte-Justine, University of Montreal, Montreal, Canada.ORCID https://orcid.org/0000-0002-6358-3771
Alfred P GillioPediatric Stem Cell and Cellular Therapy Division, Joseph M. Sanzari Children's Hospital at Hackensack Meridian Health Hackensack University Medical Center, Hackensack, NJ, USA.ORCID https://orcid.org/0000-0001-8391-3101
Hesham EissaDepartment of Pediatrics, University of Colorado, Aurora, CO, USA.ORCID https://orcid.org/0000-0001-6930-721X
Alan P KnutsenPediatric Allergy and Immunology, St. Louis University, St. Louis, MO, USA.
Victor M AquinoDepartment of Pediatrics, University of Texas Southwestern Medical Center Dallas, Dallas, TX, USA.ORCID https://orcid.org/0000-0003-2456-8621
Evan B ShereckDepartment of Pediatrics, Oregon Health & Science University, Portland, OR, USA.ORCID https://orcid.org/0000-0002-3092-7996
Theodore B MoorePediatric Blood and Marrow Transplant Program, Division of Pediatric Hematology/Oncology in the Department of Pediatrics, University of California, Los Angeles, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-7909-610X
Emi H CaywoodSidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.ORCID https://orcid.org/0000-0002-2873-6058
Mark T Vander LugtDepartment of Pediatrics, University of Michigan, Ann Arbor, MI, USA.ORCID https://orcid.org/0000-0001-9714-4454
Jacob RozmusDepartment of Pediatrics, University of British Columbia, Vancouver, Canada.ORCID https://orcid.org/0000-0003-4036-2105
Larisa BroglieCenter for International Blood and Marrow Transplant Research, Milwaukee, WI, USA.ORCID https://orcid.org/0000-0002-1674-048X
Lolie C YuLouisiana State University Health New Orleans School of Medicine, New Orleans, LA, USA.ORCID https://orcid.org/0000-0003-3898-5047
Ami J ShahDivision of Hematology/Oncology/Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford School of Medicine, Palo Alto, CA, USA.ORCID https://orcid.org/0000-0001-5700-6188
Avni Y JoshiDivision of Pediatric Allergy/Immunology, Mayo Clinic Children's Center, Rochester, MN, USA.ORCID https://orcid.org/0000-0002-7877-7261
Rebecca H BuckleyDepartment of Pediatrics, Division of Pediatric Allergy and Immunology, Duke University School of Medicine, Durham, NC, USA.ORCID https://orcid.org/0000-0002-6914-346X
Jasmeen DaraDivision of Pediatric Allergy, Immunology, and Blood and Marrow Transplantation, University of California, San Francisco, San Francisco, CA, USA.ORCID https://orcid.org/0000-0001-7459-4102
Joseph H OvedTransplant & Cellular Therapy, MSK Kids, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID https://orcid.org/0000-0002-1129-5129
Hisham Abdel AzimLoma Linda University School of Medicine, Cancer Center, Children Hospital and Medical Center, Loma Linda, CA, USA.ORCID https://orcid.org/0009-0004-9546-9334
Caridad A MartinezCell Therapy and Bone Marrow Transplant Division, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.ORCID https://orcid.org/0000-0001-7141-2457
Susan ProckopDepartment of Pediatrics, Harvard University Medical School, Boston, MA, USA.ORCID https://orcid.org/0000-0003-4175-5728
Kathleen E SullivanDivision of Allergy and Immunology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID https://orcid.org/0000-0002-3577-9021
Jack J BleesingDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID https://orcid.org/0009-0001-9588-7534
Michael D KellerDepartment of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.ORCID https://orcid.org/0000-0001-8323-3085
Lisa M MaddenPediatric Bone Marrow Transplant Program, University of California, Davis, Sacramento, CA, USA.ORCID https://orcid.org/0009-0008-3018-1144
Suhag ParikhDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.ORCID https://orcid.org/0000-0002-6066-9852
Shalini ShenoyDepartment of Pediatrics, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.ORCID https://orcid.org/0000-0002-9283-607X
Christine M SeroogyDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.ORCID https://orcid.org/0000-0002-0532-3701
Tamar RubinDivision of Pediatric Clinical Immunology and Allergy, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada.ORCID https://orcid.org/0000-0001-6386-5149
Jennifer LicataDepartment of Pediatrics, University of Colorado, Aurora, CO, USA.ORCID https://orcid.org/0009-0006-4719-8562
Jeffrey R AndolinaDepartment of Pediatrics, Golisano Children's Hospital, University of Rochester Medical Center, Rochester, NY, USA.ORCID https://orcid.org/0000-0001-6502-6859
Donald B KohnPediatric Blood and Marrow Transplant Program, Division of Pediatric Hematology/Oncology in the Department of Pediatrics, University of California, Los Angeles, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0003-1840-6087
Lauri BurroughsClinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID https://orcid.org/0000-0003-1124-4740
Jennifer W LeidingCancer and Blood Disorders Institute, Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA.ORCID https://orcid.org/0000-0002-7573-9390
Rebecca A MarshDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID https://orcid.org/0000-0002-9645-0617
Luigi D NotarangeloLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases/National Institutes of Health, Bethesda, MD, USA.ORCID https://orcid.org/0000-0002-8335-0262
Sung-Yun PaiImmune Deficiency Cellular Therapy Program, Center for Cancer Research, National Cancer Institute/National Institutes of Health, Bethesda, MD, USA.ORCID https://orcid.org/0000-0002-0158-8147
Troy R TorgersonAllen Institute for Immunology, Seattle, WA, USA.ORCID https://orcid.org/0000-0003-3489-5036
Michael A PulsipherDivision of Pediatric Hematology and Oncology, Intermountain Primary Children's Hospital, Salt Lake City, UT, USA.ORCID https://orcid.org/0000-0003-3030-8420
Jennifer HeimallDivision of Allergy and Immunology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID https://orcid.org/0000-0001-7939-5102
Geoffrey D E CuvelierPediatric Oncology and Transplantation, Alberta Children's Hospital, University of Calgary, Calgary, Canada.ORCID https://orcid.org/0000-0003-4493-8757
Linda M GriffithDivision of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases/National Institutes of Health, Bethesda, MD, USA.ORCID https://orcid.org/0009-0008-7368-3275
Jennifer M PuckDivision of Pediatric Allergy, Immunology, and Blood and Marrow Transplantation, University of California, San Francisco, San Francisco, CA, USA.ORCID https://orcid.org/0000-0001-6623-6276
Christopher C DvorakDivision of Pediatric Allergy, Immunology, and Blood and Marrow Transplantation, University of California, San Francisco, San Francisco, CA, USA.ORCID https://orcid.org/0000-0002-6146-3952
Morton J CowanDivision of Pediatric Allergy, Immunology, and Blood and Marrow Transplantation, University of California, San Francisco, San Francisco, CA, USA.ORCID https://orcid.org/0000-0002-1088-8045
Elie HaddadDepartment of Pediatrics, Department of Microbiology, Immunology and Infectious Diseases, Centre de Recherche Azrieli du CHU Sainte-Justine, University of Montreal, Montreal, Canada.ORCID https://orcid.org/0000-0003-2446-6879
Funding
Data Resource for Analyzing Blood &Marrow TransplantsU24CA076518 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Amy M Moskop, Bronwen Shaw · 1998 to 2026
$105.2MPB vs. BMU01HL069294 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI HOROWITZ, MARY MARESCA · 2001 to 2010
$63.3MTraining of Clinical Investigators in Primary Immune DeficienciesU54AI082973 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PUCK, JENNIFER M. · 2009 to 2023
$23.3MData Management and Coordinating Center (DMCC)U54NS064808 · NINDS · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2009 to 2013
$16.5MPrimary Immune Deficiency Treatment Consortium (PIDTC): A resource to drive scientific and clinical advances related to the treatment of inborn errors of immunityR24AI184316 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Christopher Craig Dvorak, Elie Haddad · 2024 to 2026
$5.3MClinical and mechanistic studies defining optimal preparative approaches to infants with IL2RG/JAK3/RAG1/RAG2 SCID: a randomized trial of busulfan dosageU01AI184132 · NIAID · NATIONAL MARROW DONOR PROGRAM · PI JEFFERY J AULETTA, Michael A Pulsipher · 2024 to 2026
$3.2MPrimary Immune Deficiency Treatment Consortium Annual Scientific MeetingR13AI094943 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PUCK, JENNIFER M. · 2011 to 2025
$239kNCI NIH HHS U24 CA076518NHLBI NIH HHS U01 HL069294NIAID NIH HHS R13 AI094943NIAID NIH HHS R24 AI184316NIAID NIH HHS U01 AI184132NIAID NIH HHS U54 AI082973NINDS NIH HHS U54 NS064808
Abstract
Black race and Hispanic ethnicity are associated with higher mortality in severe combined immunodeficiency (SCID) following hematopoietic cell transplantation (HCT), though mechanisms remain unclear. We evaluated 796 children with SCID who received nonsibling HCT between 1982 and 2020 using data from the Primary Immune Deficiency Treatment Consortium. Overall survival for Black (aHR 2.47, 95%CI 1.64, 3.71) and Asian/Pacific Islander patients (aHR 1.82, 95%CI 1.00, 3.30) was significantly lower compared with non-Hispanic White patients, while Hispanic patients had lower event-free survival (aHR 1.83, 95%CI 1.27, 2.63) compared with non-Hispanic White patients. Even after adjusting for age and infection, Black patients with SCID had more than twofold hazard of death compared with non-Hispanic White patients. NBS was associated with earlier diagnosis, reduced infection at HCT, and elimination of survival disparities between Black and non-Hispanic White patients. These findings suggest that universal, system-level interventions such as NBS can mitigate disparities in outcomes for children with SCID.
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.