ArticleMaedica2026
Clinical Evaluation of Gingival Augmentation Using Injectable Platelet-Rich Fibrin and Microneedling in Thin Periodontal Phenotype.
Article in Maedica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: In periodontology, gingival phenotype is important for both therapeutic and cosmetic reasons. Drug delivery is improved for people with a thin gingival phenotype by using DERMAPEN microneedling to introduce medications through tiny gingival microinjuries. Injectable platelet-rich fibrin (i-PRF) is a useful tool in regenerative periodontal therapy because it offers a rich source of autologous growth factors when paired with microneedling (MN). This study aimed to determine the influence of i-PRF alone and in combination with MN on gingival thickness (GT) and keratinized tissue width (KTW) in individuals with thin gingival biotypes. Materials and method: A split-mouth study with 30 participants aged 16-20 compared the effects of i-PRF alone versus i-PRF combined with MN on GT and KTW. Assessments were made at baseline and one month. Group 1 received i-PRF with MN and group 2 only i-PRF. Results: At baseline, there were no significant differences in GT and KTW scores between the two groups. After one month, the MN + i-PRF group had significantly higher GT and KTW than the i-PRF group. Both groups showed statistically significant reductions in the mean scores of gingival index, plaque index, clinical attachment level and probing pocket depth from baseline to one month. Conclusion: Microneedling and i-PRF could serve as an effective non-surgical approach to enhance GT and KTW in individuals with thin periodontal phenotypes. Both i-PRF alone and in combination with MN have the potential to improve these parameters.
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