Evidence map›Paper›PMID 42416757›Full record

ArticleMaedica2026

Impact of C-Fos Overactivation on Laryngeal Squamous Cell Carcinoma Biological Parameters.

Aristeidis Chrysovergis, Vasileios Papanikolaou, Georgios Papanastasiou, Despoina Spyropoulou, Maria Adamopoulou, Athanasios Niotis, Panagiotis Fotiades, Pavlos Pantos, Sotirios Papouliakos, Vasileios Ragos and 5 more

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In one paragraph

Article in Maedica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Aristeidis ChrysovergisDepartment of Otolaryngology, "Elpis" Hospital, Athens, Greece.
Vasileios PapanikolaouDepartment of Otolaryngology, "Sotiria" Hospital, Athens, Greece.
Georgios Papanastasiou *Department of Maxillofacial Surgery, Medical School, University of Ioannina, Greece.
Despoina Spyropoulou *Department of Radiation Oncology, Medical School, University of Patras, Patras, Greece.
Maria Adamopoulou *School of Science and Technology, Department of Science and Mathematics, Biomedical Sciences, Deree-The American College of Greece, Athens, Greece.
Athanasios Niotis *Department of Breast Surgery, "Henry Dunant" Medical Hospital, Athens, Greece.
Panagiotis FotiadesDepartment of Surgery, 424 Army General Hospital, Thessaloniki, Greece.
Pavlos Pantos1st Department of Otolaryngology, Hippokration General Hospital, Medical School, National and Kapodistrian University, Athens, Greece.
Sotirios PapouliakosDepartment of Otolaryngology, "Genimatas" Hospital, Athens, Greece.
Vasileios RagosDepartment of Maxillofacial Surgery, Medical School, University of Ioannina, Greece.
Nicholas MastronikolisDepartment of Otolaryngology, Medical School, University of Patras, Patras, Greece.
Evangelos TsiambasDepartment of Cytology, 417 Army Equity Fund Hospital (NIMTS), Athens, Greece.
Ioanna E MetaxasDepartment of Internal Medicine, "Agioi Anargyroi" General Hospital, Athens, Greece.
Napoleon-Georgios RagkosDepartment of Maxillofacial Surgery, Medical School, University of Ioannina, Greece.
Efthymios Kyrodimos1st Department of Otolaryngology, Hippokration General Hospital, Medical School, National and Kapodistrian University, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Deregulation of transcriptional factors is a severe genetic event during carcinogenetic process. Among them, C-Fos proto-oncogene (gene locus: 14q24.3) encodes for a nuclear phosphoprotein that is involved in critical intracellular functions. Our aim was to explore the impact of C-Fos different expression patterns on a series of laryngeal squamous cell carcinoma (LSCC) cases. Materials and methods: A set of fifty-five (n=55) LSCC tissues were analyzed by implementing a combination of anti-C-Fos-based immunohistochemistry and digital image analysis assays, respectively. Results: Overexpression of the molecule (high staining intensity levels) was confirmed in 34/55 (61.8%) of the selected cases, whereas the remaining 21/55 (38.2%) were characterized by low expression rates. C-Fos deregulation was marginally correlated with the stage of the examined malignancies (p=0.048), demonstrating a progressively increased protein overexpression. No further statistical correlations were established referring to gender, anatomic location, grade or tobacco and alcohol consumption, respectively. Conclusion: C-Fos oncogene overactivation is a frequent event in subgroups of LSCC patients. C-Fos overexpression seems to lead to an aggressive phenotype increased metastatic potential (advanced stage). Identifying specific C-Fos genetic signatures that lead to its overactivation should be a significant step for an optimal oncological approach by targeting the gene.

Indexed as

carcinomaFosimage analysisimmunohistochemistrylarynxoncogene

Identifiers

PMID42416757
PMCPMC13325756

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.