ArticleRSC advances2026
A dual-function host-guest antioxidant system for synergistic treatment of diquat poisoning.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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13 authors.
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Abstract
Diquat (DQ), a widely used herbicide, is highly toxic to humans. DQ ingestion can lead to severe multi-organ dysfunction and high mortality, primarily due to the lack of effective antidotes and detoxification strategies. To address this, we developed a host-guest formulation for the combinatorial treatment of DQ poisoning. This formulation encapsulates ergothioneine (EGT), a potent reactive oxygen species (ROS) scavenger, within the host molecule pillar[6]MaxQ (P6AS). The strong complexation between P6AS and both EGT and DQ was confirmed by NMR and fluorescence titration studies.
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