Alterations in resting-state functional connectivity relate to psychopathology trajectories during emerging adolescence.

Background: A general psychopathology " Methods: We examined whether baseline RSFC was prospectively related to the trajectory of Results: There was a significant nonlinear, quadratic trajectory of p-factor scores over wave. Lower within-DMN and within-DAN connectivity and greater DMN-DAN, DMN-CON, and VAN-CON connectivity were associated with higher between-person levels of p-factor scores, which persisted over time. Greater VAN-DAN and SN-CON connectivity and lower DMN-VAN connectivity were prospectively associated with steeper within-person rates of quadratic change in p-factor scores over time. Conclusion: These novel results identify specific alterations in RSFC within and between core networks involved in self-referential processing, bottom-up and town-down attention, salience, and cognitive control that might contribute to general psychopathology development in early adolescence. Children with aberrant connectivity between the DMN and VAN, SN and CON, and VAN and DAN networks may be vulnerable to increases in general psychopathology during the transition to adolescence.