ArticleAesthetic surgery journal. Open forum2026
Comparative Effects of Injectable Biostimulatory Agents (Calcium Hydroxyapatite, New Cellular Treatment Factor, VAMP, and Human Exosomes) and Their Combination on Skin Regeneration.
Article in Aesthetic surgery journal. Open forum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
Funding
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Abstract
Background: Injectable biostimulatory and bioactive agents are increasingly used to enhance dermal regeneration and improve skin quality. Polydeoxyribonucleotide (PDRN), polyrevitalizing multicomponent solutions, calcium hydroxylapatite microspheres, and human-derived exosomes have been proposed to stimulate fibroblast activity, collagen remodeling, and angiogenesis. However, direct comparative evidence in intact skin remains limited. Objectives: The aim of this study was to compare the histological and angiogenic effects of PDRN, polyrevitalizing solutions, calcium hydroxylapatite, human-derived exosomes, and their combination on dermal regeneration in intact skin using a hamster model. Methods: One hundred and sixty-eight adult Syrian hamsters were randomized into 7 groups ( Results: All active treatments increased dermal cellularity, collagen deposition, and microvessel density compared with control and saline groups. Combination therapy produced the greatest enhancements in collagen fiber density, organization, and angiogenesis, with significantly higher CD34-positive microvessel density at days 7 and 14 ( Conclusions: Injectable bioactive and biostimulatory agents enhance dermal remodeling and neovascularization in intact skin, with combination therapy targeting complementary regenerative pathways yielding the most pronounced histological effects. These findings support multimodal injectable strategies for skin rejuvenation and regenerative dermatology. Level of Evidence 4 Therapeutic:
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