Evidence map›Paper›PMID 42416600›Full record

ReviewReviews in cardiovascular medicine2026

Myocardial Infarction With Non-Obstructive Coronary Artery Disease: Exploration of the Etiology to Guide Therapy.

Angelo Giuseppe Marino, Antonio De Vita, Saverio Tremamunno, Nello Cambise, Fabio De Benedetto, Gaetano Antonio Lanza

Abstract readReview
In one paragraph

Review in Reviews in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Angelo Giuseppe MarinoDepartment of Cardiovascular Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.ORCID https://orcid.org/0009-0006-6588-6035
Antonio De VitaDepartment of Cardiovascular Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.ORCID https://orcid.org/0000-0001-8725-7447
Saverio TremamunnoDepartment of Cardiovascular Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.ORCID https://orcid.org/0000-0002-6837-6464
Nello CambiseDepartment of Cardiovascular Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.ORCID https://orcid.org/0000-0003-1538-0483
Fabio De BenedettoDepartment of Cardiovascular Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
Gaetano Antonio LanzaDepartment of Cardiovascular Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.ORCID https://orcid.org/0000-0003-2187-6653

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myocardial infarction with non-obstructive coronary artery disease (MINOCA) occurs in up to 14% of patients presenting with acute myocardial infarction. Initially considered a favorable clinical diagnosis, MINOCA is now recognized as a condition that significantly impairs quality of life and is associated with an unfavorable prognosis, including significant risks of mortality, rehospitalization, disability, and recurrent angina, all contributing to high socioeconomic costs. MINOCA is a heterogeneous condition, with multiple identified underlying mechanisms, including epicardial or microvascular spasm, rupture or erosion of an atherosclerotic coronary plaque, coronary embolism, and spontaneous coronary artery dissection. Given this complexity, a comprehensive diagnostic workup that integrates clinical assessment, advanced imaging modalities, and invasive testing is necessary for the accurate identification of the specific cause of MINOCA and to guide the selection of an appropriate, individualized therapeutic strategy for each patient. This narrative review aims to explore the etiologies of MINOCA and provide clinicians with an up-to-date overview of therapeutic advances and targeted strategies for each underlying mechanism.

Indexed as

acute coronary syndromeblood vesselcoronary dissectioncoronary thrombosiscoronary vasospasmcoronary vesselmyocardial infarction

Identifiers

PMID42416600
PMCPMC13339241

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.