ArticleReviews in cardiovascular medicine2026
Longitudinal Assessment of Cardiac Native T1 in Transfusion-Dependent Thalassemia.
Article in Reviews in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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10 authors.
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Abstract
Background: Cardiovascular magnetic resonance (CMR) T2* is the reference standard for assessing myocardial iron overload (MIO). Native T1 mapping has emerged as a complementary technique and may be more sensitive for detecting mild or early myocardial iron deposition. We evaluated longitudinal changes in native left ventricular (LV) T1 values over 18 months in patients with transfusion-dependent thalassemia (TDT). Methods: A total of 64 TDT patients consecutively enrolled in the Extension-Myocardial Iron Overload in Thalassemia (E-MIOT) project underwent two CMR examinations at 1.5T. Native T1 mapping and T2* relaxometry were performed using standardized protocols. LV T1 and T2* values were calculated from 16 myocardial segments. LV ejection fraction was assessed by cine imaging. Results: At baseline, mean LV T1 was 959.51 ± 101.46 ms and mean LV T2* was 37.17 ± 9.44 ms, with a significant correlation between the two parameters (R = 0.533; Conclusions: In well-managed TDT patients, native myocardial T1 values remain overall stable over mid-term follow-up despite marked interindividual variability. Baseline T1 values and parallel changes in T2* influence longitudinal changes in T1, supporting native T1 mapping as a complementary, but not interchangeable, tool to T2* for the assessment and longitudinal monitoring of MIO.
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