Evidence map›Paper›PMID 42416521›Full record

ArticleCase reports in oncology

Gastric Cancer Treated with 5-Fluorouracil following Discontinuation of Adjuvant S1 plus Docetaxel and Capecitabine plus Oxaliplatin due to Drug-Induced Acute Pancreatitis: A Case Report.

Yumi Takamori, Yu Aoki, Hiroaki Miyake, Yumi Amano, Kota Tanuma, Atsushi Nakazawa, Shota Hoshino, Fumiki Toriumi, Shigemichi Hirose, Shinsuke Funakoshi

Abstract readCase Reports
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In one paragraph

Article in Case reports in oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Yumi TakamoriDepartment of Medical Oncology, Tokyo Saiseikai Central Hospital, Tokyo, Japan.
Yu AokiDepartment of Medical Oncology, Tokyo Saiseikai Central Hospital, Tokyo, Japan.
Hiroaki MiyakeDepartment of Medical Oncology, Tokyo Saiseikai Central Hospital, Tokyo, Japan.
Yumi AmanoDepartment of Medical Oncology, Tokyo Saiseikai Central Hospital, Tokyo, Japan.
Kota TanumaDepartment of Gastroenterology and Hepatology, Tokyo Saiseikai Central Hospital, Tokyo, Japan.
Atsushi NakazawaDepartment of Gastroenterology and Hepatology, Tokyo Saiseikai Central Hospital, Tokyo, Japan.
Shota HoshinoDepartment of General and Gastrointestinal Surgery, Tokyo Saiseikai Central Hospital, Tokyo, Japan.
Fumiki ToriumiDepartment of General and Gastrointestinal Surgery, Tokyo Saiseikai Central Hospital, Tokyo, Japan.
Shigemichi HiroseDepartment of Diagnostic Pathology, Tokyo Saiseikai Central Hospital, Tokyo, Japan.
Shinsuke FunakoshiDepartment of Medical Oncology, Tokyo Saiseikai Central Hospital, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Drug-induced acute pancreatitis (DIAP) is a rare cause of acute pancreatitis, accounting for approximately 3-5% of cases, and reports of chemotherapy-induced pancreatitis remain limited. Case Presentation: Herein, we present the case of a 68-year-old man who developed DIAP during adjuvant chemotherapy with S-1 plus docetaxel and later with capecitabine plus oxaliplatin following surgery for gastric cancer. A drug-induced lymphocyte stimulation test (DLST) was conducted to identify the suspected agents, yielding positive results for S-1 and capecitabine, whereas docetaxel and oxaliplatin were negative. Unexpectedly, the DLST result for 5-fluorouracil was negative. Based on these findings, adjuvant chemotherapy was switched to 5-fluorouracil plus leucovorin, which was successfully continued without recurrence of pancreatitis. Shortly thereafter, the patient was diagnosed with recurrent gastric cancer. However, palliative chemotherapy with a 5-fluorouracil-based regimen was safely continued. Conclusion: Although DIAP can be fatal, the DLST may help identify the suspected causative drug and contribute to decision-making in important clinical situations such as cancer treatment.

Indexed as

Adjuvant chemotherapyDrug-induced acute pancreatitisDrug-induced lymphocyte stimulation testFluoropyrimidineGastric cancer

Identifiers

PMID42416521
PMCPMC13341106

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