ArticleTransplantation direct2026
Optimization of Valganciclovir for Treatment of Cytomegalovirus Infection in Pediatric Liver Transplant Recipients: A Prospective Pharmacokinetic Study.
Article in Transplantation direct, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
12 authors.
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Abstract
Background: Valganciclovir (VGCV) is the first-line therapeutic agent for cytomegalovirus (CMV) infection following pediatric liver transplantation (LT). The dosage for pediatric patients is either determined by body weight (BW dose) or body surface area (BSA) and renal function (7 × BSA [m Methods: We conducted a prospective pharmacokinetic study in pediatric LT patients. The area under the concentration-time curve (AUC Results: Fourteen patients with a median age of 1.1 y were included. The median VGCV dose was 15.3 mg/kg, whereas the hypothetical median BSA dose was 24.5 mg/kg. The estimated AUC Conclusions: Based on our estimation, BSA dosing may be more likely to achieve the target AUC
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