Evidence map›Paper›PMID 42416501›Full record

ReviewFrontiers in allergy2026

Pathophysiological and molecular insights into allergic conjunctivitis: an expanding analysis of immunological endotypes.

Henry Velazquez-Soto, Lorenzo Islas-Vazquez, Marisa Cruz-Aguilar, Estefanía Castillo-Balcazar, Ana X Yhmoff-Sanchez, María C Jiménez-Martínez

Abstract readReview
In one paragraph

Review in Frontiers in allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Henry Velazquez-SotoDepartment of Immunology, Research Unit, Institute of Ophthalmology Conde de Valenciana Foundation, Mexico City, Mexico.
Lorenzo Islas-VazquezDepartment of Immunology, Research Unit, Institute of Ophthalmology Conde de Valenciana Foundation, Mexico City, Mexico.
Marisa Cruz-AguilarDepartment of Immunology, Research Unit, Institute of Ophthalmology Conde de Valenciana Foundation, Mexico City, Mexico.
Estefanía Castillo-BalcazarDepartment of Immunology, Research Unit, Institute of Ophthalmology Conde de Valenciana Foundation, Mexico City, Mexico.
Ana X Yhmoff-SanchezDepartment of Immunology, Research Unit, Institute of Ophthalmology Conde de Valenciana Foundation, Mexico City, Mexico.
María C Jiménez-MartínezDepartment of Immunology, Research Unit, Institute of Ophthalmology Conde de Valenciana Foundation, Mexico City, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Allergic conjunctivitis (AC) is an ocular surface disease characterized by immune-mediated inflammation that can significantly impair quality of life. This review explores recent advances in understanding the immunological and molecular mechanisms underlying AC, highlighting local and systemic immune responses and their roles in disease pathogenesis and progression. Particular attention is given to the influence of genetic and epigenetic factors, which may contribute to individual susceptibility and variability in clinical presentation. Finally, this review discusses emerging evidence on clinical phenotypes and immunological endotypes in ocular allergy, emphasizing their relevance for the development of targeted, personalized, and precision therapies.

Indexed as

allergic conjunctivitisendotypesepigeneticsgeneticsimmunological responsemiRNAstear cytokines

Identifiers

PMID42416501
PMCPMC13337925

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.