ArticleThe journal of venomous animals and toxins including tropical diseases2026
Nephrotoxic acute kidney injury induced by
Article in The journal of venomous animals and toxins including tropical diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- From Venom to Kidney Injury: A Critical Review ofToxins · 2026Review
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Authors and funding
9 authors.
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Abstract
Background: Envenomation by Methods: Kidney tissue samples from intact rabbits ( Results: Following the administration of RVV and its venom fractions, histopathological analysis revealed extensive tubulonephrosis across all renal tubular segments in both intact kidneys and the IPK model. In contrast, renal tubular necrosis involving all tubular segments occurred in the IPK model after exposure to the RVV, PLA₂ and MP fractions. Immunohistochemical analysis revealed a trend toward increased Bax protein expression and decreased Bcl-2 expression in multiple tubular segments compared to controls in both models. RT-qPCR analysis demonstrated a 1.5-fold upregulation of Conclusions: Envenomation with RVV and its venom fractions induced nephrotoxic acute kidney injury by modulating Bax- and Bcl-2-mediated apoptosis in renal tubular epithelial cells, with greater susceptibility observed in intact kidneys and a reduced apoptotic response in the IPK model. These findings suggest that prolonged venom exposure may be partially reversible or may shift cell-death signaling from apoptosis toward necrosis.
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