ArticleInternational journal of surgery case reports2026
Primary breast diffuse large B-cell lymphoma mimicking breast carcinoma: a diagnostic challenge - case report.
Article in International journal of surgery case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Primary breast lymphoma (PBL) is a rare malignancy that may clinically and radiologically mimic breast carcinoma. Accurate pathological diagnosis is essential to guide treatment and avoid unnecessary radical surgery. Presentation of case: A 47-year-old woman presented with a painless right breast mass and ipsilateral axillary lymphadenopathy. Initial core-needle histology was interpreted as grade 2 invasive ductal carcinoma, and the patient underwent right mastectomy with axillary dissection. Postoperative immunohistochemistry (IHC) showed tumor cells positive for CD20 and negative for cytokeratin and T-cell markers, consistent with primary breast diffuse large B-cell lymphoma (PB-DLBCL). The patient received six cycles of R-CHOP and remains in complete remission at a 2-year follow-up. Discussion: PBL may be morphologically indistinguishable from carcinoma on limited H&E sections. Therefore, IHC is essential to differentiate lymphoma from epithelial malignancy; when feasible, adequate preoperative sampling and targeted immunostains should be considered to prevent unnecessary mastectomy. R-CHOP chemotherapy is the mainstay of treatment for PB-DLBCL. Conclusion: Consider PBL in the differential diagnosis of breast masses. Adequate sampling and IHC are crucial to directing appropriate, non-surgical therapy.
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