Evidence map›Paper›PMID 42416403›Full record

ArticleInternational journal of microbiology2026

Exploring Human Papillomavirus 16 Long Control Region Variants in Paraguayan Women: Comparing Variant Diversity to Transcriptional Activity and Cervical Lesion Severity.

Pamela Mongelós, Magaly Martínez, Natalia Díaz, Valéria Talpe Nunes, Adriana Valenzuela Cáceres, Alexandra Mercado-Amarilla, Mabel Miranda, Laura Bernal, Elena Kasamatsu, Malvina Páez and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Pamela MongelósHealth Sciences Research Institute (IICS), National University of Asuncion (UNA), San Lorenzo, Paraguay.ORCID https://orcid.org/0000-0002-7771-3688
Magaly MartínezHealth Sciences Research Institute (IICS), National University of Asuncion (UNA), San Lorenzo, Paraguay.ORCID https://orcid.org/0000-0003-2877-2363
Natalia DíazHealth Sciences Research Institute (IICS), National University of Asuncion (UNA), San Lorenzo, Paraguay.ORCID https://orcid.org/0000-0001-5690-2167
Valéria Talpe NunesCenter for Translational Research in Oncology, Cancer Institute of the State of Sao Paulo (ICESP), Hospital of Clinic of the Faculty of Medicine of the University of Sao Paulo (HC FMUSP), São Paulo, Brazil.ORCID https://orcid.org/0000-0001-9802-2125
Adriana Valenzuela CáceresHealth Sciences Research Institute (IICS), National University of Asuncion (UNA), San Lorenzo, Paraguay.ORCID https://orcid.org/0000-0002-0785-8371
Alexandra Mercado-AmarillaHealth Sciences Research Institute (IICS), National University of Asuncion (UNA), San Lorenzo, Paraguay.ORCID https://orcid.org/0000-0003-1958-2939
Mabel MirandaHealth Sciences Research Institute (IICS), National University of Asuncion (UNA), San Lorenzo, Paraguay.ORCID https://orcid.org/0000-0003-2914-3112
Laura BernalHealth Sciences Research Institute (IICS), National University of Asuncion (UNA), San Lorenzo, Paraguay.ORCID https://orcid.org/0009-0007-7994-2269
Elena KasamatsuHealth Sciences Research Institute (IICS), National University of Asuncion (UNA), San Lorenzo, Paraguay.ORCID https://orcid.org/0000-0002-8385-2967
Malvina PáezHealth Sciences Research Institute (IICS), National University of Asuncion (UNA), San Lorenzo, Paraguay.ORCID https://orcid.org/0000-0002-9248-027X
Amalia CastroHealth Sciences Research Institute (IICS), National University of Asuncion (UNA), San Lorenzo, Paraguay.ORCID https://orcid.org/0009-0004-2555-3127
María Isabel Rodriguez-RiverosHealth Sciences Research Institute (IICS), National University of Asuncion (UNA), San Lorenzo, Paraguay.ORCID https://orcid.org/0000-0002-7692-8628
Hernan BarriosHealth Sciences Research Institute (IICS), National University of Asuncion (UNA), San Lorenzo, Paraguay.ORCID https://orcid.org/0009-0002-4810-3845
Armando BaenaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA, nih.gov.ORCID https://orcid.org/0000-0001-8717-6911
Maryluz RolEarly Detection, Prevention and Infection Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France, who.int.ORCID https://orcid.org/0000-0003-4250-092X
Maribel AlmonteDepartment of Noncommunicable Diseases, Rehabilitation and Disability, World Health Organization, Geneva, Switzerland, who.int.ORCID https://orcid.org/0000-0003-1623-8323
Rolando HerreroCosta Rican Agency for Biomedical Research, San José, Costa Rica.ORCID https://orcid.org/0000-0001-5448-3456
Laura SicheroCenter for Translational Research in Oncology, Cancer Institute of the State of Sao Paulo (ICESP), Hospital of Clinic of the Faculty of Medicine of the University of Sao Paulo (HC FMUSP), São Paulo, Brazil.ORCID https://orcid.org/0000-0002-7999-5818
Laura MendozaHealth Sciences Research Institute (IICS), National University of Asuncion (UNA), San Lorenzo, Paraguay.ORCID https://orcid.org/0000-0001-6124-1244

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human papillomavirus Type 16 (HPV16) variants are classified into four lineages (A-D) and 16 sublineages: A1-3 (European), A4 (Asian), B1-4 and C1-4 (African), and D1-4 (Asian-American). This study investigated the genetic HPV16 variability through sequencing of the complete long control region (LCR), in 44 cervical samples from Paraguayan women, including 19 without cervical intraepithelial neoplasia grade 2 (<CIN2) and 25 with CIN2 or worse (CIN2+: 1 CIN2, 16 CIN3, and 8 invasive cancers). Sublineages A1 (81.8%), A4 (2.3%), D2 (2.3%), D3 (11.4%), and D4 (2.3%) were detected. A total of 48 point mutations were detected, of which 11 showed nominal association with CIN2+ (

Indexed as

CIN2+ lesionsHPV16long control regionParaguayan womentranscriptional activityvariants

Identifiers

PMID42416403
PMCPMC13338574

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.