ArticleFrontiers in cellular and infection microbiology2026
How mNGS transforms care for non-verbal elderly stroke patients with pneumonia.
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Stroke-associated pneumonia (SAP) is a severe complication in non-verbal elderly stroke patients, with diagnosis hindered by the low sensitivity and slow turnaround of conventional microbial culture. Methods: A single-center retrospective cohort study was conducted on 64 non-verbal elderly SAP patients (≥65 years) admitted to Guangxi Jiangbin Hospital from 2018 to 2022, divided into an mNGS group (n=30, sputum/BALF tested by metagenomic next-generation sequencing) and a control group (n=34, conventional culture). Propensity score matching (1:1) was used to balance baseline characteristics, and clinical outcomes and pathogen detection efficiency were compared between groups. Multivariable Cox regression adjusted for hypoalbuminemia, electrolyte disturbance and stroke severity. Results: mNGS detected more bacterial pathogens (37 vs.27 in sputum, 37 vs.21 in BALF) and identified 3 viral and 2 atypical pathogens undetectable by culture, with a negative rate of 13.3% (vs.20.0% for sputum culture, 43.3% for BALF culture). 73.3% of mNGS group patients received antimicrobial therapy adjustment. After adjustment, the mNGS group had notably higher 28-day (96.7% vs.76.5%; adjusted HR = 0.32, Conclusion: mNGS enables more comprehensive pathogen detection in non-verbal elderly SAP patients, guides targeted antimicrobial therapy, and is associated with improved survival and reduced healthcare resource consumption. However, large-sample multicenter prospective studies are needed to validate these findings due to the study's limitations.
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