ArticleJournal of the Endocrine Society2026
Bone and joint quality remains impaired in long-term controlled acromegaly: an HR-pQCT study.
Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Context: Joint and bone disorders are frequent, disabling complications of acromegaly that progress despite biochemical remission. HR-pQCT provides a precise assessment of bone and joint quality. Objective: To evaluate joint and bone quality in patients with long-term controlled acromegaly. Design: Cross-sectional study. Participants: 17 acromegaly patients and 17 age- and sex-matched controls. Measures: HR-pQCT of hand joints, tibia, and radius; bone microindentation; vertebral fracture assessment; dual X-ray absorptiometry; circulating bone biomarkers; questionnaires. Results: Patients with acromegaly (mean age: 61.8 years, mean disease duration: 13.1 years, mean IGF-I xULN: 0.9) had wider joint spaces of the second (2.85 vs 2.68 mm, Conclusion: Long-term, biochemically controlled acromegaly is associated with structural joint alterations and impaired bone microarchitecture, even years after diagnosis.
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