Evidence map›Paper›PMID 42416177›Full record

ArticleAlpha psychiatry2026

Association of Adverse Childhood Experiences With Health-Related Quality of Life and Quality-Adjusted Life-Years Among Adolescents in the United Kingdom: Findings From Two General Population Cohorts.

Amarech Obse, Kamaldeep Bhui, Laura Havers, Sania Shakoor, Georgina Hosang, Siobhan Hugh-Jones, Minhua Ma, Anna Mankee-Williams, Alexis Karamanos, Seeromanie Harding and 1 more

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Article in Alpha psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Amarech ObseThe Institute for Lifecourse Development, University of Greenwich, Old Royal Naval College, Park Row, SE10 9LS London, UK.ORCID https://orcid.org/0000-0002-4299-9559
Kamaldeep BhuiDepartment of Psychiatry, Nuffield Department of Primary Care Health Sciences, and Wadham College, University of Oxford, OX3 7JX Oxford, UK.
Laura HaversCentre for Psychiatry and Mental Health, Wolfson Institute of Population Health, Queen Mary, University of London, E1 4NS London, UK.
Sania ShakoorCentre for Psychiatry and Mental Health, Wolfson Institute of Population Health, Queen Mary, University of London, E1 4NS London, UK.
Georgina HosangCentre for Psychiatry and Mental Health, Wolfson Institute of Population Health, Queen Mary, University of London, E1 4NS London, UK.
Siobhan Hugh-JonesSchool of Psychology, University of Leeds, LS2 9JT Leeds, UK.
Minhua MaDepartment of Psychiatry, University of Oxford, OX3 7JX Oxford, UK.
Anna Mankee-WilliamsResearch and Innovation Department, Falmouth University, TR10 9FE Falmouth, UK.
Alexis KaramanosDepartment of Population Health Sciences, School of Life Course & Population Sciences, Faculty of Life Sciences and Medicine, King's College London, SE1 1UL London, UK.
Seeromanie HardingDepartment of Population Health Sciences, School of Life Course & Population Sciences, Faculty of Life Sciences and Medicine, King's College London, SE1 1UL London, UK.
Paul McCroneThe Institute for Lifecourse Development, University of Greenwich, Old Royal Naval College, Park Row, SE10 9LS London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Evidence on the impact of adverse childhood experiences (ACEs) on multidimensional wellbeing, including health-related quality of life (HRQoL) and quality-adjusted life-years (QALYs), remains inadequate, particularly among young people. This study examines how ACEs and their interactions with sex, ethnicity, and socioeconomic status (SES) are associated with HRQoL and QALYs in United Kingdom (UK) adolescents. Methods: Baseline and follow-up data from the Determinants of Adolescent Social Well-being and Health (DASH) Study (N = 6648) and HeadStart Cornwall (HeadStart) (N = 4575) were used. ACE data were sourced from self-reports and official records and measured as binary and count variables. The Strengths and Difficulties Questionnaire (SDQ) was mapped to the Child Health Utility 9D (CHU9D) to calculate utility values for QALY estimation. Results: Over the 3- and 2-year follow-up periods, mean accumulated QALYs were 2.30 (standard error [SE]: 0.002) (DASH) and 1.45 (SE: 0.004) (HeadStart). The occurrence of any ACEs, self-reported and officially recorded, respectively, reduced QALYs by 0.064 (SE: 0.021) (DASH) and 0.060 (SE: 0.021) (HeadStart). These translate to losses of 23 (DASH) and 22 (HeadStart) days over the follow-up period. A greater count of ACEs was associated with stronger effects. Dose-dependent interactions were significant only for ACEs-ethnicity and ACEs-sex (≥2 ACEs), with White adolescents and females experiencing greater QALY losses as the number of ACEs increased. Conclusions: ACEs, whether self-reported or officially recorded, were associated with greater QALY losses, with the strength of association increasing as the number of ACEs increased. Furthermore, White and female adolescents exposed to a greater number of ACEs had the highest QALY losses. Further studies are needed to investigate the moderation of these associations and the mechanisms underlying the associations between ACEs and HRQoL/QALYs to inform targeted interventions.

Indexed as

adolescentadverse childhood experienceshealth-related quality of lifequality-adjusted life-yearUnited Kingdom

Identifiers

PMID42416177
PMCPMC13339791

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.