ArticleJournal of clinical practice and research2026
Loganin Attenuates Psoriasis-Like Inflammation by Regulating the NLRP3 Inflammasome-SIRT1 Axis in Keratinocytes.
Article in Journal of clinical practice and research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: The development of psoriasis involves disrupted signaling interactions between immune components and keratinocytes, leading to a chronic autoimmune state characterized by sustained inflammatory responses and epidermal hyperplasia. This study aimed to elucidate the anti-inflammatory potential of loganin (LOG) against the inflammasome-SIRT1 signaling pathway in a CaCl Materials and Methods: HaCaT cells were differentiated using CaCl Results: Differentiation of HaCaT cells was induced by CaCl Conclusion: LOG exerts potent anti-psoriatic effects by suppressing NLRP3 inflammasome-mediated pyroptosis and restoring apoptotic competence in hyperproliferative keratinocytes through SIRT1 activation. These findings highlight LOG as a promising translational candidate for targeting keratinocyte-driven inflammation in psoriasis and warrant further preclinical and clinical investigation.
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