ArticleSeparation and purification technology2026
Purifying circRNA by ultrafiltration with membranes having well-defined pores.
Article in Separation and purification technology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Circular RNA (circRNA) is a promising therapeutic modality owing to its enhanced stability conferred by exonuclease resistance. However, large-scale production remains limited by inefficient purification methods, as the standard approach using size-exclusion chromatography suffers from peak overlap and low yield. Here, we present an ultrafiltration strategy for purifying circRNA using polycarbonate track-etched membranes with precisely controlled pore diameters. Membrane pore sizes were fine-tuned by gold plating to separate circular and linear RNA conformers. Sieving coefficients of purified RNA conformers were measured to establish operating conditions, and continuous diafiltration experiments were conducted within the range of flux values predicted to achieve both high purity and yield. This approach resulted in 94% purity and 59% yield of circRNA from
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