Evidence map›Paper›PMID 42416080›Full record

ArticleFrontiers in immunology2026

Immunogenicity and protective potential of a mucosal protein-only vaccine candidate for tuberculosis.

A C Tran, M Y Kim, E J Vergara, M J Paul, D Burnsall, M Das, J E Pearl, A M Cooper, Rajko Reljic

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

A C TranInstitute for Infection and Immunity, School of Health and Medical Sciences, City St. George's University of London, London, United Kingdom.
M Y KimInstitute for Infection and Immunity, School of Health and Medical Sciences, City St. George's University of London, London, United Kingdom.
E J VergaraInstitute for Infection and Immunity, School of Health and Medical Sciences, City St. George's University of London, London, United Kingdom.
M J PaulInstitute for Infection and Immunity, School of Health and Medical Sciences, City St. George's University of London, London, United Kingdom.
D BurnsallDepartment of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom.
M DasDepartment of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom.
J E PearlDepartment of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom.
A M CooperDepartment of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom.
Rajko ReljicInstitute for Infection and Immunity, School of Health and Medical Sciences, City St. George's University of London, London, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the widespread use of the BCG vaccine, tuberculosis remains a leading global health threat. The primary limitation of BCG lies in its failure to prevent pulmonary TB in adults, largely due to its systemic administration route which fails to induce robust mucosal immunity at the site of primary infection. This study evaluates a novel mucosal vaccine platform, TB-PCF, incorporating

Indexed as

Antigens, BacterialBacterial ProteinsImmunogenicity, VaccineMycobacterium tuberculosisTuberculosisTuberculosis, PulmonaryTuberculosis VaccinesAnimalsAntibodies, BacterialCholera ToxinFemaleImmunity, MucosalLungMiceMice, Inbred C57BLProtein Subunit VaccinesAntibodies, BacterialAntigens, BacterialBacterial ProteinsCholera ToxinESAT-6 protein, Mycobacterium tuberculosisesxB protein, MycobacteriumProtein Subunit VaccinesTuberculosis VaccinesinfectionlungmicemucosalTB vaccine

Identifiers

PMID42416080
PMCPMC13337862

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.