ReviewFrontiers in microbiology2026
A review of current evidence and perspectives on the mechanisms and clinical significance of hypoxia-induced remodeling of the gastric microbiota-metabolism axis.
Review in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypoxia, as a critical environmental factor, significantly influences the gastric microbiota. The microbiota-metabolism axis profoundly influences host health and disease through its effects on microbial composition and metabolic processes. This review examines how gastric hypoxia affects microbial populations in distinct ways and how these metabolic changes may contribute to gastric disorders. Integrating recent insights from molecular biology and metabolomics, we elucidate the mechanisms underlying microbial dysbiosis in hypoxic environments and their impact on downstream signaling pathways. These findings implicate this axis in the pathogenesis of gastritis, gastric ulcers, and gastric cancer. Finally, we discuss key considerations for future clinical implementation, acknowledging that the current evidence base remains largely observational and indirect. Moreover, we offer a novel perspective on the interplay between hypoxia, bacteria, and metabolism within the gastric niche.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.