ArticleFrontiers in cardiovascular medicine2026
Sex-specific echocardiographic remodeling and prognostic value of left ventricular sphericity, pressure-dimension index, and myocardial work after durable LVAD implantation.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Sex-related differences in outcomes after left ventricular assist device (LVAD) implantation are recognized, yet the structural mechanisms remain incompletely defined. We evaluated sex-specific remodeling patterns and the prognostic value of ventricular geometry and non-invasive myocardial work (MW). Methods: We performed a retrospective analysis of 103 adults (85 men, 18 women) undergoing durable LVAD implantation. Primary endpoints were changes in left ventricular sphericity index (LVSI) and RV pressure-dimension index (PDI) from baseline to 6 months. Adjusted models (ANCOVA with robust standard errors) and quantile regression were used to assess sex effects, with robustness examined by a 1:2 propensity score matching analysis (matching on age, BMI, clinical profile, and device). Predictors of mortality and postoperative right heart failure (RHF) were assessed using Cox and logistic regression models, respectively. Results: Baseline geometry and myocardial work were similar between sexes. Post-implantation, men exhibited adverse sphericalization (median ΔLVSI +0.045, Conclusion: In this exploratory cohort, women showed preserved LV geometry and PDI after LVAD implantation, but findings require cautious interpretation due to small sample size and attenuation after matching. LVSI and myocardial work may support future risk stratification studies.
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