ArticleNeurosciences (Riyadh, Saudi Arabia)2026
Relationships Between the Corpus Callosum Index and Current Blood Parameters and Temporal Changes in these Parameters in Patients with Multiple Sclerosis.
Article in Neurosciences (Riyadh, Saudi Arabia), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: This study aimed to investigate changes in blood parameters and examine the relationships among the corpus callosum index (CCI), plaque characteristics, and blood parameters in multiple sclerosis (MS) patients. In MS, the CCI is associated with brain atrophy and disease progression. Methods: In this retrospective, cross-sectional study, demographic data from 103 MS patients (38 males), along with blood parameters obtained five years earlier and current values, were analyzed in relation to magnetic resonance imaging (MRI) findings. The CCI calculated from MRI scans was assessed in relation to plaque distribution and number. Statistical analyses included paired sample t tests, Wilcoxon tests, and Spearman correlation analysis. Results: Current lymphocyte, platelet, and monocyte levels were significantly lower than those measured five years earlier ( Conclusion: In MS patients, the CCI is negatively associated with the SII, plaque distribution, and plaque number and positively associated with the MNR. A decreased MNR and increased SII are linked to corpus callosum atrophy.
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