Evidence map›Paper›PMID 42415963›Full record

ArticleChemistrySelect2025

Synthesis of β-fluoropyrrolidines designed to reduce hERG affinity in a class of antiparasitic compounds.

Tanner J Schubert, Guadalupe Calixto, Katelyn B Richter, Suvajit Koley, Linglin Dai, Jose Teixeira, Emily Philo, Christopher D Huston, Micky D Tortorella, Xiaoping Chen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemistrySelect, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tanner J SchubertDepartment of Chemistry, School of Science and Engineering, Saint Louis University, Saint Louis, MO 63103.
Guadalupe CalixtoDepartment of Chemistry, School of Science and Engineering, Saint Louis University, Saint Louis, MO 63103.
Katelyn B RichterDepartment of Chemistry, School of Science and Engineering, Saint Louis University, Saint Louis, MO 63103.
Suvajit KoleyDepartment of Chemistry, School of Science and Engineering, Saint Louis University, Saint Louis, MO 63103.
Linglin DaiGuangzhou Institutes for Biomedicine and Health, Chinese Academy of Sciences.
Jose TeixeiraUniversity of Vermont Larner College of Medicine, Burlington, VT 05405.
Emily PhiloDepartment of Chemistry, School of Science and Engineering, Saint Louis University, Saint Louis, MO 63103.
Christopher D HustonUniversity of Vermont Larner College of Medicine, Burlington, VT 05405.
Micky D TortorellaGuangzhou Institutes for Biomedicine and Health, Chinese Academy of Sciences.
Xiaoping ChenGuangzhou Institutes for Biomedicine and Health, Chinese Academy of Sciences.
Marvin J MeyersDepartment of Chemistry, School of Science and Engineering, Saint Louis University, Saint Louis, MO 63103.

Funding

Preclinical optimization of a parasiticidal drug for cryptosporidiosisR01AI143951 · NIAID · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HUSTON, CHRISTOPHER D, MEYERS, MARVIN J · 2019 to 2023
$3.3M
NIAID NIH HHS R01 AI143951
6 · The paper itself

Abstract

Malaria is a parasitic disease caused by the parasite

Indexed as

CryptosporidiosisCryptosporidiumdrug discoveryfluorinehERGmalariaPlasmodium

Identifiers

PMID42415963
PMCPMC13340594

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.