ReviewInternational journal of nanomedicine2026
Biomaterial-Based Strategies for Gout Therapy: Recent Advances, Current Challenges, and Future Perspectives - A Review.
Review in International journal of nanomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gout is a complex and progressive inflammatory disease caused by the deposition of monosodium urate (MSU) crystals. Recent research on the application of biomaterials in gout treatment has shown promising potential. Biomaterials, with their unique biocompatibility, controlled release properties, and targeted delivery capabilities, offer significant advantages in enhancing drug solubility and bioavailability, reducing systemic adverse effects, and enabling more precise and stage-specific therapeutic intervention. In this review, we systematically categorize the various biomaterials applied in gout therapy over the past five years, including nano-drug delivery systems, microneedle drug delivery systems, and novel biomaterial-based therapeutics for gout treatment. We highlight the design principles, construction strategies, and mechanisms of action associated with each type of biomaterial. By comparatively analyzing the functions of different biomaterial platforms, this review further summarizes their potential therapeutic roles, relative advantages, and current limitations in gout management. In addition, we discuss currently used gout-related animal models and their relevance to preclinical evaluation, and synthesize emerging therapeutic targets that may guide future biomaterial design. Overall, this review highlights both the opportunities and the translational challenges of biomaterial-based strategies for gout therapy, providing insights for the development of more targeted, effective, and clinically relevant therapeutic approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.