Evidence map›Paper›PMID 42415849›Full record

ArticlebioRxiv : the preprint server for biology2026

scRNA-seq and genomics analyses reveal key mechanisms of inverted papilloma-associated sinonasal squamous cell carcinoma malignant transformation.

Tolani F Olonisakin, Fernando T Zamuner, Kenny Vu, Sreenivasulu Gunti, Yiming Ding, Yue Hou, Xinping Yang, Ramya Viswanathan, Angel Huynh, Federico Comoglio and 15 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Tolani F OlonisakinSinonasal and Skull Base Tumor Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Fernando T ZamunerDepartment of Otolaryngology - Head and Neck Surgery, Johns Hopkins Medicine, Baltimore, MD, USA.ORCID 0000-0002-6106-4361
Kenny VuSinonasal and Skull Base Tumor Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Sreenivasulu GuntiSinonasal and Skull Base Tumor Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Yiming DingDepartment of Otolaryngology, Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, People's Republic of China.
Yue HouAkoya Biosciences Inc, Marlborough, MA, USA.
Xinping YangSection on Translational Tumor Immunology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Ramya ViswanathanSinonasal and Skull Base Tumor Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Angel HuynhSection on Translational Tumor Immunology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Federico ComoglioenGene Statistics GmbH, Basel, Switzerland.
Marco NotaroenGene Statistics GmbH, Basel, Switzerland.
Christopher CherryC.M. Cherry Consulting, Baltimore, MD, USA.
Michael PatatanianC.M. Cherry Consulting, Baltimore, MD, USA.
Nathan WongAdvanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Timothy R DeKlotzDepartment of Otolaryngology - Head and Neck Surgery, MedStar Georgetown University Hospital, Washington, DC, USA.
Jean KimDepartment of Otolaryngology - Head and Neck Surgery, Johns Hopkins Medicine, Baltimore, MD, USA.
Wayne KochDepartment of Otolaryngology - Head and Neck Surgery, Johns Hopkins Medicine, Baltimore, MD, USA.
Andrew P LaneDepartment of Otolaryngology - Head and Neck Surgery, Johns Hopkins Medicine, Baltimore, MD, USA.
Murugappan RamanathanDepartment of Otolaryngology - Head and Neck Surgery, Johns Hopkins Medicine, Baltimore, MD, USA.
Nicholas R RowanDepartment of Otolaryngology - Head and Neck Surgery, Johns Hopkins Medicine, Baltimore, MD, USA.
Matt LechnerDivision of Surgery and Interventional Science and UCL Cancer Institute, University College London, London, UK.
Aaron UdagerDepartment of Pathology, University of Michigan, Ann Arbor, MI, USA.
Evgeny IzumchenkoDepartment of Medicine, Section of Hematology and Oncology, University of Chicago, Chicago, IL, USA.
Clint T AllenSection on Translational Tumor Immunology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Nyall R LondonSinonasal and Skull Base Tumor Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6M
NIH HHS 75N91019D00024
6 · The paper itself

Abstract

Sinonasal inverted papilloma (IP) carries a 10% risk of malignant transformation to IP-associated sinonasal squamous cell carcinoma (IP-SNSCC), yet the molecular and immune drivers of this progression remain poorly defined. This study integrates single-cell RNA sequencing, multiplexed spatial proteomics, whole-exome sequencing, and functional assays across IP and IP-SNSCC cohorts to define mechanisms of malignant transformation. Respiratory epithelial basal cells are identified as the putative cell of origin, with progression marked by recurrent

Identifiers

PMID42415849
PMCPMC13334782

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.