ArticleClinical kidney journal2026
Long-term survival and mortality predictors in a Swedish cohort of patients with ANCA-positive vasculitis and severe kidney involvement.
Article in Clinical kidney journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: To describe the clinical characteristics of a Swedish cohort of patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) and kidney involvement and to study long-term survival and predictors of all-cause mortality. Methods: An observational study including patients with AAV and kidney involvement between 1993 and 2023 from two centres in mid-Sweden. Data were obtained from electronic health care records and follow-up visits. Multivariable Cox regression models and Kaplan-Meier analysis were performed to evaluate risk factors of interest predicting all-cause mortality. Results: Among 190 patients (56% men, median age 67 years, 43% PR3-ANCA (Proteinase 3 Anti-Neutrophil Cytoplasmic Antibody), and 57% MPO -ANCA (Myeloperoxidase Anti-Neutrophil Cytoplasmic Antibody) positive, estimated glomerular filtration rate at diagnosis was 23 ml/min/1.73 m Conclusion: Long-term patient and kidney survival was associated mainly with age and serum albumin levels at diagnosis in this Swedish cohort of patients with AAV. Infections and cardiovascular disease were the most common causes of death, underscoring the importance of infection monitoring and cardiovascular risk management.
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