Evidence map›Paper›PMID 42415814›Full record

ArticlePhoton science2026

The Use of Synchrotron Radiation in the Medical Sciences.

Lydia Osborn, Jamie L Inman, Corie Y Ralston

Abstract read
In one paragraph

Article in Photon science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lydia OsbornMolecular Foundry Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.ORCID 0009-0009-3806-8514
Jamie L InmanBiological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.ORCID 0000-0002-6056-1219
Corie Y RalstonMolecular Foundry Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.ORCID 0000-0002-7899-0951

Funding

User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Gregory L Hura · 2017 to 2026
$28.6M
Development of high-dose time-resolved x-ray footprinting technologies to enable the next level of structural analysis for challenging biological problemsR01GM126218 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI RALSTON, CORIE Y · 2018 to 2025
$3.4M
NIGMS NIH HHS P30 GM124169NIGMS NIH HHS R01 GM126218
6 · The paper itself

Abstract

Synchrotron radiation (SR) sources provide unparalleled brilliance, collimation, coherence, and tunability, enabling specialized techniques that are crucial for advancing medical research across diverse fields from radiation oncology to rational drug design. Certain SR methods, such as macromolecular crystallography, are highly developed and automated, and have been used for decades for both fundamental understanding of biomolecules as well as pharmaceutical design, while other methods, such as microbeam radiation therapy, represent relatively recent developments. Scattering and diffraction methods using SR can provide atomic-level structural mapping of proteins, nucleic acids, and complexes. Imaging applications using SR continue to be developed and advanced for mapping of biological structures and potential use as diagnostics in disease detection. Spectroscopic methods are used to study elemental distributions relevant for detection of contamination in biological systems. Collectively, SR research delivers detailed multiscale structural and molecular information essential for addressing complex biomedical challenges. In this mini-review, we cover SR methods that are specifically relevant to medical applications, focusing mainly on SR X-ray and SR infrared techniques and applications. We include diffraction and scattering, imaging, absorption and fluorescent spectroscopy, use of SR in oncology treatments, and radiation damage methods that integrate one or another aspect of an SR method in conjunction with other non-SR techniques.

Indexed as

biomedical X-ray applicationsradiation treatmentsynchrotron-based medical researchsynchrotron facilitiesX-ray imaging

Identifiers

PMID42415814
PMCPMC13340870

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.